ABE-induced PDGFD start codon silencing unveils new insights into the genetic architecture of sheep fat tails

doi: 10.1016/j.jgg.2023.07.008

• Peter Kalds ^1,2 , 
• Shuhong Huang ¹ , 
• Siyuan Xi ¹ , 
• Yumeng Fang ¹ , 
• Yawei Gao ¹ , 
• Shiwei Zhou ^1,3 , 
• Kexin Sun ¹ , 
• Chao Li ¹ , 
• Bei Cai ^1,4 , 
• Yao Liu ¹ , 
• Yige Ding ¹ , 
• Qifang Kou ⁵ , 
• Tad Sonstegard ⁶ , 
• Björn Petersen ⁷ , 
• Stephen Kemp ⁸ , 
• Baohua Ma ³ , 
• Jian-Lin Han ^8,9     , 
• Yulin Chen ^1,10     , 
• Xiaolong Wang ^1,10    

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  1 International Joint Agriculture Research Center for Animal Bio-breeding, Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China;

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  2 Department of Animal and Poultry Production, Faculty of Environmental Agricultural Sciences, Arish University, El-Arish 45511, Egypt;

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  3 College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China;

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  4 Key Laboratory of Ruminant Molecular and Cellular Breeding, School of Agriculture, Ningxia;

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  University, Yinchuan 750000, China;

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  5 Ningxia Tianyuan Tan Sheep Farm, Hongsibu 751999, China;

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  6 Acceligen Inc., St. Paul, MN 55104, United States;

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  7 Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Mariensee, Neustadt am Rübenberge 31535, Germany;

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  8 International Livestock Research Institute (ILRI), Nairobi 30709-00100, Kenya;

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  9 CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China;

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  10 Key Laboratory of Livestock Biology, Northwest A&F University, Yangling 712100, China