Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos

doi: 10.1016/j.jgg.2022.02.010

• Yubing Liu ¹ , 
• Xinmei Lu ² , 
• Min Ye ³ , 
• Ling Wang ⁴ , 
• Rongxin Tang ⁴ , 
• Zhiyong Yang ⁴ , 
• Bongkoch Turathum ⁵ , 
• Chenchen Liu ⁶ , 
• Yujing Xue ⁶ , 
• Menghua Wu ⁶ , 
• Yannan Yang ⁶ , 
• Ermeng Gao ⁶ , 
• Di Zhang ⁶ , 
• Feng Yang ⁶ , 
• Keh-Kooi Kee ⁷ , 
• Xingxu Huang ⁸ , 
• Guanglei Li ⁸     , 
• Ri-Cheng Chian ⁹    

•  

  1. Center for Reproductive Medicine, Tenth People's Hospital of Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China;

•  

  2. Center for Reproductive Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China;

•  

  3. Center for Stem Cell Biology and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;

•  

  4. Center for Reproductive Medicine, Tenth People's Hospital of Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China;

•  

  5. Department of Basic Medical Science, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand;

•  

  6. Center for Reproductive Medicine, Tenth People's Hospital of Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China;

•  

  7. Center for Stem Cell Biology and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;

•  

  8. School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Pudong New Area, Shanghai 201210, China;

•  

  9. Center for Reproductive Medicine, Tenth People's Hospital of Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China