Induced pluripotent stem cells (iPSCs)—a new era of reprogramming

Lan Kang; Zhaohui Kou; Yu Zhang; Shaorong Gao

doi:10.1016/S1673-8527(09)60060-6

Volume 37 Issue 7

Jul. 2010

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Article Navigation > Journal of Genetics and Genomics > 2010 > 37(7): 415-421

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Induced pluripotent stem cells (iPSCs)—a new era of reprogramming

doi: 10.1016/S1673-8527(09)60060-6

National Institute of Biological Sciences, NIBS, Beijing 102206, China

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Corresponding author: E-mail address: gaoshaorong@nibs.ac.cn (Shaorong Gao)
Received Date: 2010-03-22
Accepted Date: 2010-04-20
Rev Recd Date: 2010-04-09

Available Online: 2010-07-24

Publish Date: 2010-07-20

Abstract

Abstract

Embryonic stem cells (ESCs) derived from the early embryos possess two important characteristics: self-renewal and pluripotency, which make ESCs ideal seed cells that could be potentially utilized for curing a number of degenerative and genetic diseases clinically. However, ethical concerns and immune rejection after cell transplantation limited the clinical application of ESCs. Fortunately, the recent advances in induced pluripotent stem cell (iPSC) research have clearly shown that differentiated somatic cells from various species could be reprogrammed into pluripotent state by ectopically expressing a combination of several transcription factors, which are highly enriched in ESCs. This ground-breaking achievement could circumvent most of the limitations that ESCs faced. However, it remains challenging if the iPS cell lines, especially the human iPSCs lines, available are fully pluripotent. Therefore, it is prerequisite to establish a molecular standard to distinguish the better quality iPSCs from the inferior ones.
- induced pluripotent stem cells (iPSCs),
- reprogramming,
- molecular events

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