Current Articles

2024, Volume 51,  Issue 12

Review
Sex chromosome turnover and biodiversity in fishes
Jingrong Wang, Wenjing Tao, Thomas D. Kocher, Deshou Wang
2024, 51(12): 1351-1360. doi: 10.1016/j.jgg.2024.08.008
Abstract (16) PDF (0)
Abstract:

The impact of sex chromosomes and their turnover in speciation remains a subject of ongoing debate in the field of evolutionary biology. Fishes are the largest group of vertebrates, and they exhibit unparalleled sexual plasticity, as well as diverse sex-determining (SD) genes, sex chromosomes, and s...

Nanopore sequencing: flourishing in its teenage years
Tianyuan Zhang, Hanzhou Li, Mian Jiang, Huiyu Hou, Yunyun Gao, Yali Li, Fuhao Wang, Jun Wang, Kai Peng, Yong-Xin Liu
2024, 51(12): 1361-1374. doi: 10.1016/j.jgg.2024.09.007
Abstract (6) PDF (0)
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Over the past decade, nanopore sequencing has experienced significant advancements and changes, transitioning from an initially emerging technology to a significant instrument in the field of genomic sequencing. However, as advancements in next-generation sequencing technology persist, nanopore sequ...

Original Research
Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1
Yayue Chen, Delai Huang, Aixuan Xie, Ying Shan, Shuyi Zhao, Ce Gao, Jun Chen, Hui Shi, Weihuan Fang, Jinrong Peng
2024, 51(12): 1375-1388. doi: 10.1016/j.jgg.2024.09.011
Abstract (10) PDF (0)
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Mutations in calcium-dependent papain-like protease CALPAIN3 (CAPN3) cause Limb-Girdle Muscular Dystrophy Recessive Type 1 (LGMDR1), the most common limb-girdle muscular dystrophy in humans. In addition to progressive muscle weakness, persistent inflammatory infiltration is also a feature of LGMDR1....

RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model
Ji-Won Park, Tae-Ik Choi, Tae-Yoon Kim, Yu-Ri Lee, Dilan Wellalage Don, Jaya K. George-Abraham, Laurie A. Robak, Cristina C. Trandafir, Pengfei Liu, Jill A. Rosenfeld, Tae Hyeong Kim, Florence Petit, Yoo-Mi Kim, Chong Kun Cheon, Yoonsung Lee, Cheol-Hee Kim
2024, 51(12): 1389-1403. doi: 10.1016/j.jgg.2024.09.016
Abstract (12) PDF (0)
Abstract:

Williams syndrome (WS) is a rare multisystemic disorder caused by recurrent microdeletions on 7q11.23, characterized by intellectual disability, distinctive craniofacial and dental features, and cardiovascular problems. Previous studies have explored the roles of individual genes within these microd...

Nitrogen inhibition of nitrogenase activity involves the modulation of cytosolic invertase in soybean nodule
Qinzhen Xu, Xin Wang, Nan Wang, Suning Li, Xiaolei Yao, Huaqin Kuang, Zhimin Qiu, Danxia Ke, Wenqiang Yang, Yuefeng Guan
2024, 51(12): 1404-1412. doi: 10.1016/j.jgg.2024.06.013
Abstract (3) PDF (0)
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Legume symbiotic nitrogen fixation (SNF) is suppressed by inorganic nitrogen (N) in the soil. High N inhibition of nitrogenase activity is associated with the deprivation of carbon allocation and metabolism in nodules. However, the underlying molecular mechanisms remain unclear. Here, we identify Gm...

A single-nucleotide polymorphism in PvPW1 encoding β-1,3-glucanase 9 is associated with pod width in Phaseolus vulgaris L.
Kun Xu, Jinlong Zhu, Hong Zhai, Qiang Yang, Keqin Zhou, Qijian Song, Jing Wu, Dajun Liu, Yanhua Li, Zhengjun Xia
2024, 51(12): 1413-1422. doi: 10.1016/j.jgg.2024.09.020
Abstract (4) PDF (0)
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Pod width influences pod size, shape, yield, and consumer preference in snap beans (Phaseolus vulgaris L.). In this study, we map PvPW1, a quantitative trait locus associated with pod width in snap beans, through genotyping and phenotyping of recombinant plants. We identify Phvul.006G072800, encodin...

Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and molQTL analyses
Conghao Zhong, Xiaochang Li, Dailu Guan, Boxuan Zhang, Xiqiong Wang, Liang Qu, Huaijun Zhou, Lingzhao Fang, Congjiao Sun, Ning Yang
2024, 51(12): 1423-1434. doi: 10.1016/j.jgg.2024.09.003
Abstract (4) PDF (0)
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Chicken body weight (BW) is a critical trait in breeding. Although genetic variants associated with BW have been investigated by genome-wide association studies (GWAS), the contributions of causal variants and their molecular mechanisms remain largely unclear in chickens. In this study, we construct...

CtIP regulates G2/M transition and bipolar spindle assembly during mouse oocyte meiosis
Wei Yue, Hong-Yong Zhang, Heide Schatten, Tie-Gang Meng, Qing-Yuan Sun
2024, 51(12): 1435-1446. doi: 10.1016/j.jgg.2024.09.005
Abstract (7) PDF (0)
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CtBP-interacting protein (CtIP) is known for its multifaceted roles in DNA repair and genomic stability, directing the homologous recombination-mediated DNA double-stranded break repair pathway via DNA end resection, an essential error-free repair process vital for genome stability. Mammalian oocyte...

ATN-161 alleviates caerulein-induced pancreatitis
Rong-rong Gao, Lan-yue Ma, Jian-wei Chen, Yu-xiang Wang, Yu-yan Li, Zi-yuan Zhou, Zhao-hua Deng, Jing Zhong, Ya-hai Shu, Yang Liu, Qi Chen
2024, 51(12): 1447-1458. doi: 10.1016/j.jgg.2024.10.002
Abstract (4) PDF (0)
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Pancreatitis is a common gastrointestinal disorder that causes hospitalization with significant morbidity and mortality. The mechanistic pathophysiology of pancreatitis is complicated, limiting the discovery of pharmacological intervention methods. Here, we show that the administration of ATN-161, a...

bmp10 maintains cardiac function by regulating iron homeostasis
Ruiqin Hu, Genfang Li, Peng Hu, Hongbo Niu, Wenhao Li, Shouwen Jiang, Guijun Guan, Qianghua Xu, Mingli Liu, Liangbiao Chen
2024, 51(12): 1459-1473. doi: 10.1016/j.jgg.2024.10.003
Abstract (3) PDF (0)
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Heart disease remains the leading cause of death worldwide. Iron imbalance, whether deficiency or overload, contributes to heart failure. However, the molecular mechanisms governing iron homeostasis in the heart are poorly understood. Here, we demonstrate that mutation of bmp10, a heart-born morphog...

Method
Synchronized lineage tracing of cell membranes and nuclei by dual recombinases and dual fluorescent
Xueying Yang, Shun He, Xufeng Li, Zhihou Guo, Haichang Wang, Zhuonan Zhang, Xin Song, Ke Jia, Lingjuan He, Bin Zhou
2024, 51(12): 1474-1484. doi: 10.1016/j.jgg.2024.07.006
Abstract (6) PDF (0)
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Genetic lineage tracing has been widely employed to investigate cell lineages and fate. However, conventional reporting systems often label the entire cytoplasm, making it challenging to discern cell boundaries. Additionally, single Cre-loxP recombination systems have limitations in tracing specific...

A programmable CRISPR/dCas9-based epigenetic editing system enabling loci-targeted histone citrullination and precise transcription regulation
Xiaoya Zhang, Abhisek Bhattacharya, Chunxiang Pu, Yan Dai, Jia Liu, Lang Rao, Chaoguang Tian
2024, 51(12): 1485-1493. doi: 10.1016/j.jgg.2024.05.010
Abstract (6) PDF (0)
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Histone citrullination, an important post-translational modification mediated by peptidyl arginine deiminases, is essential for many physiological processes and epigenetic regulation. However, the causal relationship between histone citrullination and specific gene regulation remains unresolved. In ...

A-to-G/C/T and C-to-T/G/A dual-function base editor for creating multi-nucleotide variants
Bingxiu Ma, Han Wu, Shixue Gou, Meng Lian, Cong Xia, Kaiming Yang, Long Jin, Junyuan Liu, Yunlin Wu, Yahai Shu, Haizhao Yan, Zhanjun Li, Liangxue Lai, Yong Fan
2024, 51(12): 1494-1504. doi: 10.1016/j.jgg.2024.10.001
Abstract (4) PDF (0)
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Multi-nucleotide variants (MNVs) are critical genetic variants associated with various genetic diseases. However, tools for precisely installing MNVs are limited. In this study, we present the development of a dual-base editor, BDBE, by integrating TadA-dual and engineered human N-methylpurine DNA g...

Research Communications
CancerSRT: a spatially resolved transcriptomics database for human cancers
Yuying Huo, Jiakang Wang, Chengcheng Liu, Jinxia Wang, Chen Wang, Wenbo Guo, Zhiyuan Yuan, Tiantian Guo, Jin Gu, Xiangyu Li
2024, 51(12): 1505-1508. doi: 10.1016/j.jgg.2024.08.012
Abstract (2) PDF (0)
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HMG-3 contributes to meiotic chromosome maintenance and inhibits reproductive aging in C. elegans
Fengguo Zhang, Yuanyuan Liu, Yanmei Li, Xiuxiu Liu, Yingchun Zhang, Guohai Su
2024, 51(12): 1509-1512. doi: 10.1016/j.jgg.2024.08.005
Abstract (6) PDF (0)
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Variants within KIF5B are associated with weight loss through mitochondrial transport alteration in sheep
Jieran Chen, Haitao Wang, Tingting Li, Yuting Zhang, Yan Chen, Na Zhang, Hengqian Yang, Zhichao Zhang, Ziyuan Duan, Xia Li, Daxiang Wang, Zhixiong He, Fan Hu, Jianfeng Gao, Runlin Z. Ma, Xun Huang, Qiuyue Liu
2024, 51(12): 1513-1516. doi: 10.1016/j.jgg.2024.09.009
Abstract (4) PDF (0)
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Localized production of LECT2 by orthotopic histiocytes during inflammation
Zhenhan Huang, Xiaojun Yang, Xun Qin, Kemin Chen, Wei Liu, Jin Xu, Jianchao Li, Wenqing Zhang, Zhibin Huang
2024, 51(12): 1517-1520. doi: 10.1016/j.jgg.2024.09.017
Abstract (5) PDF (0)
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The ABF transcription factor TaABF2 interacts with TaSnRK2s to ameliorate drought tolerance in wheat
Linying Du, Ming Yu, Qiannan Wang, Zhenbing Ma, Shumin Li, Li Ding, Fangfang Li, Weijun Zheng, Xiaojing Wang, Hude Mao
2024, 51(12): 1521-1524. doi: 10.1016/j.jgg.2024.09.022
Abstract (3) PDF (0)
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FishCODE: a web-based information platform for comprehensive omics data exploration in fish research
Heng Li, Wanting Zhang, Keyi Ren, Hong Yang, Lei Zhang, Waqar Younas, Yingyin Cheng, Yaping Wang, Mijuan Shi, Xiao-Qin Xia
2024, 51(12): 1525-1528. doi: 10.1016/j.jgg.2024.09.019
Abstract (7) PDF (0)
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A haplotype-resolved genome reveals the genetic basis of spine formation in Atelerix albiventris
Libo Jiang, Jianing Xu, Mengyuan Zhu, Zhongfan Lv, Zemin Ning, Fengtang Yang
2024, 51(12): 1529-1532. doi: 10.1016/j.jgg.2024.06.012
Abstract (7) PDF (0)
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