8.2
CiteScore
6.6
Impact Factor

2021 Vol. 48, No. 6

Commentary
Calcium channels at the center of nucleotide-binding leucine-rich repeat receptor-mediated plant immunity
Shitou Xia, Xueru Liu, Yuelin Zhang
2021, 48(6): 429-432. doi: 10.1016/j.jgg.2021.06.003
Abstract (371) HTML PDF (45)
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Review
Polycomb-group proteins in the initiation and progression of cancer
Xiujuan Zhao, Xudong Wu
2021, 48(6): 433-443. doi: 10.1016/j.jgg.2021.03.013
Abstract (186) HTML PDF (6)
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The Polycomb group (PcG) proteins are a family of chromatin regulators and critical for the maintenance of cellular identity. The PcG machinery can be categorized into at least three multi-protein complexes, namely Polycomb Repressive Complex 1 (PRC1), PRC2, and Polycomb Repressive DeUBiquitinase (P...

Original research
Genome editing in plants with MAD7 nuclease
Qiupeng Lin, Zixu Zhu, Guanwen Liu, Chao Sun, Dexing Lin, Chenxiao Xue, Shengnan Li, Dandan Zhang, Caixia Gao, Yanpeng Wang, Jin-Long Qiu
2021, 48(6): 444-451. doi: 10.1016/j.jgg.2021.04.003
Abstract (551) HTML PDF (89)
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MAD7 is an engineered nuclease of the Class 2 type V-A CRISPR-Cas (Cas12a/Cpf1) family with a low level of homology to canonical Cas12a nucleases. It has been publicly released as a royalty-free nuclease for both academic and commercial use. Here, we demonstrate that the CRISPR-MAD7 system can be us...

LIMK2 is required for membrane cytoskeleton reorganization of contracting airway smooth muscle
Yeqiong Li, Yuwei Zhou, Pei Wang, Tao Tao, Lisha Wei, Ye Wang, Wei Wang, Yanyan Zheng, Zhihui Jiang, Tiantian Qiu, Wei Zhao, Jie Sun, Xin Chen, Xue-Na Zhang, Min-Sheng Zhu
2021, 48(6): 452-462. doi: 10.1016/j.jgg.2021.04.014
Abstract (179) HTML PDF (12)
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Airway smooth muscle (ASM) has developed a mechanical adaption mechanism by which it transduces force and responds to environmental forces, which is essential for periodic breathing. Cytoskeletal reorganization has been implicated in this process, but the regulatory mechanism remains to be determine...

Molecular basis for the selective recognition and ubiquitination of centromeric histone H3 by yeast E3 ligase Psh1
Ning Zhou, Liuxin Shi, Shan Shan, Zheng Zhou
2021, 48(6): 463-472. doi: 10.1016/j.jgg.2021.04.007
Abstract (357) HTML PDF (249)
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Centromeres are chromosomal loci marked by histone variant CenH3 (centromeric histone H3) and essential for genomic stability and cell division. The budding yeast E3 ubiquitin ligase Psh1 selectively recognizes the yeast CenH3 (Cse4) for ubiquitination and controls the cellular level of Cse4 for pro...

Genomic insight into the divergence and adaptive potential of a forgotten landrace G. hirsutum L. purpurascens
Mian Faisal Nazir, Shoupu He, Haris Ahmed, Zareen Sarfraz, Yinhua Jia, Hongge Li, Gaofei Sun, Muhammad Shahid Iqbal, Zhaoe Pan, Xiongming Du
2021, 48(6): 473-484. doi: 10.1016/j.jgg.2021.04.009
Abstract (405) HTML PDF (28)
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Wild progenitors are an excellent source for strengthening the genetic basis and accumulation of desirable variation lost because of directional selection and adaptation in modern cultivars. Here, we re-evaluate a landrace of Gossypium hirsutum, formerly known as Gossypium purpurascens. Our study se...

OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice
Xiaodong Xin, Xingwang Li, Junkai Zhu, Xiaobin Liu, Zhenghu Chu, Jiali Shen, Changyin Wu
2021, 48(6): 485-496. doi: 10.1016/j.jgg.2021.04.011
Abstract (251) HTML PDF (40)
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Meiotic recombination is essential for reciprocal exchange of genetic information between homologous chromosomes and their subsequent proper segregation in sexually reproducing organisms. MLH1 and MLH3 belong to meiosis-specific members of the MutL-homolog family, which are required for normal level...

Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility
Miriam Zuccalà, Nadia Barizzone, Elena Boggio, Luca Gigliotti, Melissa Sorosina, Chiara Basagni, Roberta Bordoni, Ferdinando Clarelli, Santosh Anand, Eleonora Mangano, Domizia Vecchio, Elena Corsetti, Serena Martire, Simona Perga, Daniela Ferrante, Alberto Gajofatto, Andrei Ivashynka, Claudio Solaro, Roberto Cantello, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi, Federica Esposito, Maurizio Leone, Gianluca De Bellis, Umberto Dianzani, Filippo Martinelli-Boneschi, Sandra D'Alfonso
2021, 48(6): 497-507. doi: 10.1016/j.jgg.2021.03.017
Abstract (158) HTML PDF (13)
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Among multiple sclerosis (MS) susceptibility genes, the strongest non-human leukocyte antigen (HLA) signal in the Italian population maps to the TNFSF14 gene encoding LIGHT, a glycoprotein involved in dendritic cell (DC) maturation. Through fine-mapping in a large Italian dataset (4,198 patients wit...

Letter to the editor
Single-cell transcriptomic profiling of non-hematopoietic circulating cells in mid-gestational mouse embryos
Yanyan Li, Yanjuan Chen, Xiaona Zheng, Yun Gao, Yuxuan Zheng, Zongcheng Li, Han He, Fuchou Tang, Bing Liu, Yu Lan
2021, 48(6): 508-511. doi: 10.1016/j.jgg.2021.05.002
Abstract (332) HTML PDF (23)
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ROS is essential for initiation of energy deprivation-induced autophagy
Choufei Wu, Yixing Li, Shu Zhong, Yingcong Chen, Yu Xie, Yuyao Feng, Weijing Yao, Suping Fu, Yanlan Zhu, Liefeng Wang, Yuting Chen, Liqin Zhang, Jingjing Tong, Cong Yi
2021, 48(6): 512-515. doi: 10.1016/j.jgg.2021.05.005
Abstract (268) HTML PDF (23)
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