8.2
CiteScore
6.6
Impact Factor

2017 Vol. 44, No. 9

Editorial
Sparks of the CRISPR explosion: Applications in medicine and agriculture
Ji-Long Liu
2017, 44(9): 413-414. doi: 10.1016/j.jgg.2017.09.006
Abstract (79) HTML PDF (3)
Abstract:
Review
Gene editing in T cell therapy
Yongping Zhang, Wei Mu, Haoyi Wang
2017, 44(9): 415-422. doi: 10.1016/j.jgg.2017.09.002
Abstract (91) HTML PDF (6)
Abstract:
The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise. Gene editing holds tremendous potential for further improvements of T cell therapy. Here we review the applications of gene editing i...
APOBEC: From mutator to editor
Bei Yang, Xiaosa Li, Liqun Lei, Jia Chen
2017, 44(9): 423-437. doi: 10.1016/j.jgg.2017.04.009
Abstract (147) HTML PDF (9)
Abstract:
APOBECs (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) are a family of cytidine deaminases that prefer single-stranded nucleic acids as substrates. Besides their physiological functions, APOBEC family members have been found to cause hypermutations of cancer genomes, which could ...
Key elements for designing and performing a CRISPR/Cas9-based genetic screen
Wanjing Shang, Fei Wang, Gaofeng Fan, Haopeng Wang
2017, 44(9): 439-449. doi: 10.1016/j.jgg.2017.09.005
Abstract (121) HTML PDF (3)
Abstract:
Reverse genetic screens are invaluable for uncovering gene functions, but are traditionally hampered by some technical limitations. Over the past few years, since the advent of the revolutionary CRISPR/Cas9 technology, its power in genome editing has been harnessed to overcome the traditional limita...
Original research
Tissue-specific genome editing of laminA/C in the posterior silk glands of Bombyx mori
Yuanyuan Liu, Sanyuan Ma, Jiasong Chang, Tong Zhang, Xiaogang Wang, Run Shi, Jianduo Zhang, Wei Lu, Yue Liu, Qingyou Xia
2017, 44(9): 451-459. doi: 10.1016/j.jgg.2017.09.003
Abstract (85) HTML PDF (3)
Abstract:
The RNA-guided CRISPR/Cas9 system has been shown to be a powerful tool for genome editing in various organisms. A comprehensive toolbox for multiplex genome editing has been developed for the silkworm, Bombyx mori, a lepidopteran model insect of economic importance. However, as previous methods main...
Letter to the editor
Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene editing
Leixin Wei, Xiukun Wang, Suming Yang, Wen Yuan, Jinsong Li
2017, 44(9): 461-463. doi: 10.1016/j.jgg.2017.07.004
Abstract (109) HTML PDF (3)
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Generation of thermosensitive male-sterile maize by targeted knockout of the ZmTMS5 gene
Jun Li, Huawei Zhang, Xiaomin Si, Youhui Tian, Kunling Chen, Jinxing Liu, Huabang Chen, Caixia Gao
2017, 44(9): 465-468. doi: 10.1016/j.jgg.2017.02.002
Abstract (229) HTML PDF (17)
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Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing
Yubing He, Tao Zhang, Ning Yang, Meilian Xu, Lang Yan, Lihao Wang, Rongchen Wang, Yunde Zhao
2017, 44(9): 469-472. doi: 10.1016/j.jgg.2017.08.003
Abstract (242) HTML PDF (6)
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