Journal of Genetics and Genomics

Understanding the mechanistic regulation of ferroptosis in cancer: the gene matters

Min Gao, Kexin Fan, Yuhan Chen, Guangjian Zhang, Jing Chen, Yilei Zhang

2022, 49(10): 913-926. doi: 10.1016/j.jgg.2022.06.002

Abstract (453) PDF (30)

Abstract:
Ferroptosis has emerged as a crucial regulated cell death involved in a variety of physiological processes or pathological diseases, such as tumor suppression. Though initially being found from anticancer drug screening and considered not essential as apoptosis for growth and development, numerous s...

Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells

Siyu Chen, Zhiquan Liu, Hao Yu, Liangxue Lai, Zhanjun Li

2022, 49(10): 927-933. doi: 10.1016/j.jgg.2022.03.007

Abstract (323) PDF (16)

Abstract:
CRISPR/Cas9 system is a robust genome editing platform in biotechnology and medicine. However, it generally produces small insertions/deletions (indels, typically 1–3 bp) but rarely induces larger deletions in specific target sites. Here, we report a cytidine deaminase-Cas9 fusion-induced deletion s...

Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness

Wei Qian, Manfei Zhang, Kaiwen Wan, Yunxia Xie, Siyuan Du, Jiarui Li, Xiongzheng Mu, Jiange Qiu, Xiangyang Xue, Xiahai Zhuang, Yingzhi Wu, Fan Liu, Sijia Wang

2022, 49(10): 934-942. doi: 10.1016/j.jgg.2022.02.020

Abstract (201) PDF (23)

Abstract:
Facial and cranial variation represent a multidimensional set of highly correlated and heritable phenotypes. Little is known about the genetic basis explaining this correlation. We develop a software package ALoSFL for simultaneous localization of facial and cranial landmarks from head computed tomo...

The shikimate pathway regulates programmed cell death

Xuerui Lu, Shixi Shi, Chong Wu, Xueao Zheng, Chenkun Yang, Jie Luo, Shunping Yan

2022, 49(10): 943-951. doi: 10.1016/j.jgg.2022.02.001

Abstract (309) PDF (41)

Abstract:
Programmed cell death (PCD) is essential for both plant development and stress responses including immunity. However, how plants control PCD is not well-understood. The shikimate pathway is one of the most important metabolic pathways in plants, but its relationship to PCD is unknown. Here, we show ...

The SNAPc complex mediates starvation-induced trans-splicing in Caenorhabditis elegans

Xinhao Hou, Chengming Zhu, Mingjing Xu, Xiangyang Chen, Cheng Sun, Björn Nashan, Shouhong Guang, Xuezhu Feng

2022, 49(10): 952-964. doi: 10.1016/j.jgg.2022.02.024

Abstract (172) PDF (8)

Abstract:
Dietary restriction usually suppresses biosynthesis but activates catabolic pathways in animals. However, the short-term starvation enhances biosynthetic activities and promotes ribosomal biogenesis in adult Caenorhabditis elegans. The mechanism underlying the processes remains largely unknown. Here...

Sources of transcription variation in Plasmodium falciparum

Lindsey B. Turnbull, Katrina A. Button-Simons, Nestor Agbayani, Michael T. Ferdig

2022, 49(10): 965-974. doi: 10.1016/j.jgg.2022.03.008

Abstract (244) PDF (9)

Abstract:
Variation in transcript abundance can contribute to both short-term environmental response and long-term evolutionary adaptation. Most studies are designed to assess differences in mean transcription levels and do not consider other potentially important and confounding sources of transcriptional va...

Long-read sequencing and de novo assembly of the cynomolgus macaque genome

Bing Bai, Yi Wang, Ran Zhu, Yaolei Zhang, Hong Wang, Guangyi Fan, Xin Liu, Hong Shi, Yuyu Niu, Weizhi Ji

2022, 49(10): 975-978. doi: 10.1016/j.jgg.2021.12.013

Abstract (323) PDF (72)

Abstract:

An efficient screening system to identify protein–protein or protein–DNA interaction partners of rice transcription factors

Qingmei Su, Fang Zhang, Yunping Xiao, Pingping Zhang, Hefei Xing, Fan Chen

2022, 49(10): 979-981. doi: 10.1016/j.jgg.2022.02.007

Abstract (519) PDF (81)

Abstract:

Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos

Yubing Liu, Xinmei Lu, Min Ye, Ling Wang, Rongxin Tang, Zhiyong Yang, Bongkoch Turathum, Chenchen Liu, Yujing Xue, Menghua Wu, Yannan Yang, Ermeng Gao, Di Zhang, Feng Yang, Keh-Kooi Kee, Xingxu Huang, Guanglei Li, Ri-Cheng Chian

2022, 49(10): 982-985. doi: 10.1016/j.jgg.2022.02.010

Abstract (748) PDF (31)

Abstract:

Arabidopsis CAP1 mediates ammonium-regulated root hair growth by influencing vesicle trafficking and the cytoskeletal arrangement in root hair cells

Juanjuan Yu, Xiaonan Ma, Lianlian Wang, Nannan Dong, Kai Wang, Qingye You, Yifei Xu, Chong Wang, Zhiping Dong, Zhaobin Shi, Shaojun Dai, Ling Bai, Chun-Peng Song

2022, 49(10): 986-989. doi: 10.1016/j.jgg.2022.02.005

Abstract (372) PDF (48)

Abstract:

2022 Vol. 49, No. 10