Journal of Genetics and Genomics

Nucleolus-localized Def-CAPN3 protein degradation pathway and its role in cell cycle control and ribosome biogenesis

Shuyi Zhao, Delai Huang, Jinrong Peng

2021, 48(11): 955-960. doi: 10.1016/j.jgg.2021.06.011

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Abstract:
The nucleolus, as the ‘nucleus of the nucleus’, is a prominent subcellular organelle in a eukaryocyte. The nucleolus serves as the centre for ribosome biogenesis, as well as an important site for cell-cycle regulation, cellular senescence, and stress response. The protein composition of the nucleolu...

TEAseq-based identification of 35,696 Dissociation insertional mutations facilitates functional genomic studies in maize

Mingjie Lyu, Huafeng Liu, Joram Kiriga Waititu, Ying Sun, Huan Wang, Junjie Fu, Yanhui Chen, Jun Liu, Lixia Ku, Xiliu Cheng

2021, 48(11): 961-971. doi: 10.1016/j.jgg.2021.07.010

Abstract (300) PDF (28)

Abstract:
In plants, transposable element (TE)-triggered mutants are important resources for functional genomic studies. However, conventional approaches for genome-wide identification of TE insertion sites are costly and laborious. This study developed a novel, rapid, and high-throughput TE insertion site id...

Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups

Mingyue Cheng, Xueling Ge, Chaofang Zhong, Ruiqing Fu, Kang Ning, Shuhua Xu

2021, 48(11): 972-983. doi: 10.1016/j.jgg.2021.09.002

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Abstract:
Understanding the micro-coevolution of the human gut microbiome with host genetics is challenging but essential in both evolutionary and medical studies. To gain insight into the interactions between host genetic variation and the gut microbiome, we analyzed both the human genome and gut microbiome ...

Cochlear hair cells of echolocating bats are immune to intense noise

Zhen Liu, Peng Chen, Yuan-Yuan Li, Meng-Wen Li, Qi Liu, Wen-Lu Pan, Dong-Ming Xu, Jing Bai, Li-Biao Zhang, Jie Tang, Peng Shi

2021, 48(11): 984-993. doi: 10.1016/j.jgg.2021.06.007

Abstract (236) HTML PDF (35)

Abstract:
Exposure to intense noise can damage cochlear hair cells, leading to hearing loss in mammals. To avoid this constraint, most mammals have evolved in relatively quiet environments. Echolocating bats, however, are naturally exposed to continuous intense sounds from their own and neighboring sonar emis...

Genetic diversity and population structure of Leptosphaeria maculans isolates in Western Canada

Qilin Chen, Gary Peng, Randy Kutcher, Fengqun Yu

2021, 48(11): 994-1006. doi: 10.1016/j.jgg.2021.06.019

Abstract (218) PDF (27)

Abstract:
Leptosphaeria maculans is a serious concern for canola production worldwide. For effective disease management, knowledge of the pathogen's genetic variability and population structure is a prerequisite. In this study, whole-genome sequencing was performed for 162 of 1590 L. maculans isolates collect...

A hypothetical model of trans-acting R-loops-mediated promoter-enhancer interactions by Alu elements

Xue Bai, Feifei Li, Zhihua Zhang

2021, 48(11): 1007-1019. doi: 10.1016/j.jgg.2021.07.005

Abstract (279) PDF (30)

Abstract:
Enhancers modulate gene expression by interacting with promoters. Models of enhancer-promoter interactions (EPIs) in the literature involve the activity of many components, including transcription factors and nucleic acid. However, the role that sequence similarity plays in EPIs remains largely unex...

Mycobacterium Lrp/AsnC family transcriptional factor modulates the arginase pathway as both a sensor and a transcriptional repressor

Shuangquan Yan, Junfeng Zhen, Yuzhu Li, Yu Huang, Xuefeng Ai, Yue Li, Andrea Stojkoska, Xue Huang, Cao Ruan, Jiang Li, Lin Fan, Jianping Xie

2021, 48(11): 1020-1031. doi: 10.1016/j.jgg.2021.06.018

Abstract (153) PDF (12)

Abstract:
L-Arginine is the precursor of nitric oxide (NO), a host immune effector against intracellular pathogens including Mycobacterium tuberculosis (M. tb). Pathogens including M. tb have evolved various strategies targeting arginine to block the production of NO for better survival and proliferation. How...

The HuaBiao project: whole-exome sequencing of 5000 Han Chinese individuals

Meng Hao, Weilin Pu, Yi Li, Shaoqing Wen, Chang Sun, Yanyun Ma, Hongxiang Zheng, Xingdong Chen, Jingze Tan, Guoqing Zhang, Menghan Zhang, Shuhua Xu, Yi Wang, Hui Li, Jiucun Wang, Li Jin

2021, 48(11): 1032-1035. doi: 10.1016/j.jgg.2021.07.013

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Abstract:

Establishment of transposase-assisted low-input m⁶A sequencing technique

Tao Chen, Yan Li, Dong-Zhao Ma, Zhang Zhang, Jian-Fei Xi, Guan-Zheng Luo

2021, 48(11): 1036-1039. doi: 10.1016/j.jgg.2021.08.007

Abstract (627) PDF (118)

Abstract:

A backbone parent contributes core genomic architecture to pedigree breeding of early-season indica rice

Junyu Chen, Huali Zhang, Shuhan Deng, Huilong Du, Zhuo Chen, Yuhui Zhao, Dongqing Dai, Chengzhen Liang, Ximing Li, Chengzhi Liang, Rui Zhang, Liangyong Ma

2021, 48(11): 1040-1043. doi: 10.1016/j.jgg.2021.07.011

Abstract (237) PDF (33)

Abstract:

2021 Vol. 48, No. 11