8.2
CiteScore
6.6
Impact Factor

2013 Vol. 40, No. 6

Display Method:
Review
TALENs: Customizable Molecular DNA Scissors for Genome Engineering of Plants
Kunling Chen, Caixia Gao
2013, 40(6): 271-279. doi: 10.1016/j.jgg.2013.03.009
Abstract (104) HTML PDF (2)
Abstract:
Precise genome modification with engineered nucleases is a powerful tool for studying basic biology and applied biotechnology. Transcription activator-like effector nucleases (TALENs), consisting of an engineered specific (TALE) DNA binding domain and a Fok I cleavage domain, are newly developed ver...
TALEN or Cas9 – Rapid, Efficient and Specific Choices for Genome Modifications
Chuanxian Wei, Jiyong Liu, Zhongsheng Yu, Bo Zhang, Guanjun Gao, Renjie Jiao
2013, 40(6): 281-289. doi: 10.1016/j.jgg.2013.03.013
Abstract (109) HTML PDF (5)
Abstract:
Precise modifications of complex genomes at the single nucleotide level have been one of the big goals for scientists working in basic and applied genetics, including biotechnology, drug development, gene therapy and synthetic biology. However, the relevant techniques for making these manipulations ...
Short Tandem Target Mimic: A Long Journey to the Engineered Molecular Landmine for Selective Destruction/Blockage of MicroRNAs in Plants and Animals
Guiliang Tang, Xiaoqing Tang
2013, 40(6): 291-296. doi: 10.1016/j.jgg.2013.02.004
Abstract (93) HTML PDF (0)
Abstract:
MicroRNAs (miRNAs) are a population of highly conserved specific small ribo-regulators that negatively regulate gene expressions in both plants and animals. They play a key role in post-transcriptional gene regulation by destabilizing the target gene transcripts or blocking protein translation from ...
Original research
Characterization of the Drosophila Atlastin Interactome Reveals VCP as a Functionally Related Interactor
Niamh C. O'Sullivan, Nina Dräger, Cahir J. O'Kane
2013, 40(6): 297-306. doi: 10.1016/j.jgg.2013.04.008
Abstract (85) HTML PDF (0)
Abstract:
At least 25 genes, many involved in trafficking, localisation or shaping of membrane organelles, have been identified as causative genes for the neurodegenerative disorder hereditary spastic paraplegia (HSP). One of the most commonly mutated HSP genes, atlastin-1, encodes a dynamin-like GTPase that ...
Characterization and Fine Mapping of a Necrotic Leaf Mutant in Maize (Zea mays L.)
Lijing Wang, Shuai Han, Shiyi Zhong, Haizhong Wei, Yanjun Zhang, Yan Zhao, Baoshen Liu
2013, 40(6): 307-314. doi: 10.1016/j.jgg.2013.04.004
Abstract (66) HTML PDF (0)
Abstract:
Maize (Zea mays L.) is a commercially important crop. Its yield can be reduced by mutations in biosynthetic and degradative pathways that cause death. In this paper, we describe the necrotic leaf (nec-t) mutant, which was obtained from an inbred line, 81647. The nec-t mutant plants had yellow leaves...
Letter to the Editor
Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis
Changsheng Xing, Xiaoying Fu, Xiaodong Sun, Jin-Tang Dong
2013, 40(6): 315-318. doi: 10.1016/j.jgg.2013.04.005
Abstract (59) HTML PDF (0)
Abstract:
Directed Evolution of Insoluble Arabidopsis thaliana Zeta Class Glutathione S-Transferase Mutants for Higher Solubility in Escherichia coli
Yicun Wang, Feng Zhang, Haiwei Chen, Xiwen Chen, Defu Chen
2013, 40(6): 319-322. doi: 10.1016/j.jgg.2013.03.005
Abstract (72) HTML PDF (0)
Abstract: