Journal of Genetics and Genomics

2013 Vol. 40, No. 6

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Review
Original research
Letter to the Editor

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Review

TALENs: Customizable Molecular DNA Scissors for Genome Engineering of Plants

Kunling Chen, Caixia Gao

2013, 40(6): 271-279. doi: 10.1016/j.jgg.2013.03.009

Abstract (104) HTML PDF (2)

Abstract:
Precise genome modification with engineered nucleases is a powerful tool for studying basic biology and applied biotechnology. Transcription activator-like effector nucleases (TALENs), consisting of an engineered specific (TALE) DNA binding domain and a Fok I cleavage domain, are newly developed ver...

TALEN or Cas9 – Rapid, Efficient and Specific Choices for Genome Modifications

Chuanxian Wei, Jiyong Liu, Zhongsheng Yu, Bo Zhang, Guanjun Gao, Renjie Jiao

2013, 40(6): 281-289. doi: 10.1016/j.jgg.2013.03.013

Abstract (115) HTML PDF (5)

Abstract:
Precise modifications of complex genomes at the single nucleotide level have been one of the big goals for scientists working in basic and applied genetics, including biotechnology, drug development, gene therapy and synthetic biology. However, the relevant techniques for making these manipulations ...

Short Tandem Target Mimic: A Long Journey to the Engineered Molecular Landmine for Selective Destruction/Blockage of MicroRNAs in Plants and Animals

Guiliang Tang, Xiaoqing Tang

2013, 40(6): 291-296. doi: 10.1016/j.jgg.2013.02.004

Abstract (93) HTML PDF (0)

Abstract:
MicroRNAs (miRNAs) are a population of highly conserved specific small ribo-regulators that negatively regulate gene expressions in both plants and animals. They play a key role in post-transcriptional gene regulation by destabilizing the target gene transcripts or blocking protein translation from ...

Original research

Characterization of the Drosophila Atlastin Interactome Reveals VCP as a Functionally Related Interactor

Niamh C. O'Sullivan, Nina Dräger, Cahir J. O'Kane

2013, 40(6): 297-306. doi: 10.1016/j.jgg.2013.04.008

Abstract (85) HTML PDF (0)

Abstract:
At least 25 genes, many involved in trafficking, localisation or shaping of membrane organelles, have been identified as causative genes for the neurodegenerative disorder hereditary spastic paraplegia (HSP). One of the most commonly mutated HSP genes, atlastin-1, encodes a dynamin-like GTPase that ...

Characterization and Fine Mapping of a Necrotic Leaf Mutant in Maize (Zea mays L.)

Lijing Wang, Shuai Han, Shiyi Zhong, Haizhong Wei, Yanjun Zhang, Yan Zhao, Baoshen Liu

2013, 40(6): 307-314. doi: 10.1016/j.jgg.2013.04.004

Abstract (66) HTML PDF (0)

Abstract:
Maize (Zea mays L.) is a commercially important crop. Its yield can be reduced by mutations in biosynthetic and degradative pathways that cause death. In this paper, we describe the necrotic leaf (nec-t) mutant, which was obtained from an inbred line, 81647. The nec-t mutant plants had yellow leaves...

Letter to the Editor

Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis

Changsheng Xing, Xiaoying Fu, Xiaodong Sun, Jin-Tang Dong

2013, 40(6): 315-318. doi: 10.1016/j.jgg.2013.04.005

Abstract (59) HTML PDF (0)

Abstract:

Directed Evolution of Insoluble Arabidopsis thaliana Zeta Class Glutathione S-Transferase Mutants for Higher Solubility in Escherichia coli

Yicun Wang, Feng Zhang, Haiwei Chen, Xiwen Chen, Defu Chen

2013, 40(6): 319-322. doi: 10.1016/j.jgg.2013.03.005

Abstract (72) HTML PDF (0)

Abstract:

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