8.2
CiteScore
6.6
Impact Factor

2010 Vol. 37, No. 9

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Research article
An everlasting role of animal models in understanding human disease
Yang Xiao, Yang Chonglin
2010, 37(9) doi: 10.1016/S1673-8527(09)60075-8
Abstract (116) HTML PDF (0)
Abstract:
Now and future of mouse mutagenesis for human disease models
Yoichi Gondo
2010, 37(9): 559-572. doi: 10.1016/S1673-8527(09)60076-X
Abstract (229) HTML PDF (0)
Abstract:
One of the major objectives of the Human Genome Project is to understand the biological function of the gene and genome as well as to develop clinical applications for human diseases. For this purpose, the experimental validations and preclinical trails by using animal models are indispensable. The ...
The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis
Minhua Zheng, Zifeng Zhang, Xingcheng Zhao, Yuqiang Ding, Hua Han
2010, 37(9): 573-582. doi: 10.1016/S1673-8527(09)60077-1
Abstract (108) HTML PDF (0)
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The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neovascularization-associated diseases in adults, such as diabet...
TGF-β signaling in aortic aneurysm: another round of controversy
Fuyu Lin, Xiao Yang
2010, 37(9): 583-591. doi: 10.1016/S1673-8527(09)60078-3
Abstract (110) HTML PDF (1)
Abstract:
Aortic aneurysm (AA) is a common health problem with high mortality and no effective drugs. Transforming growth factor-β (TGF-β) superfamily members regulate various cellular processes, and TGF-β signaling has key roles in development, tissue homeostasis, and diseases. Interest in the role of TGF-β ...
Wg signaling in Drosophila heart development as a pioneering model
Xiushan Wu
2010, 37(9): 593-603. doi: 10.1016/S1673-8527(09)60079-5
Abstract (126) HTML PDF (0)
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The heart is one of the first functional embryonic organs occurring during development. The fundamental developmental processes and genes involved in cardiogenesis are conserved between the invertebrates and vertebrates. In the past fifteen years, one of signaling pathways that has been best charact...
POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila
Ming Zhang, Yongqing Zhang, Zhiheng Xu
2010, 37(9): 605-619. doi: 10.1016/S1673-8527(09)60080-1
Abstract (121) HTML PDF (1)
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TNFα can trigger different signaling pathways, including the JNK pathway, to regulate various biological functions such as cell death, differentiation and proliferation. The scaffold protein POSH (Plenty of SH3 Domains) has been shown to be an important regulator of the JNK pathway, but whether it i...
A small scale expression screen identifies tissue specific markers in the Dugesia japonica strain Pek-1
Changxin Ma, Xiaoan Wang, Shuizhou Yu, Guoliang Chai, Hanxia Su, Liang Zheng, Wei Wu
2010, 37(9): 621-635. doi: 10.1016/S1673-8527(09)60081-3
Abstract (106) HTML PDF (2)
Abstract:
Freshwater planaria has tremendous capacity to reform the missing part of the body and therefore is considered as one of the most important model organism for regeneration study. At present,Schmidtea mediterranea and Dugesia japonica are the two major species utilized for laboratory manipulations. D...
Embryonic expression and evolutionary analysis of the amphioxus Dickkopf and Kremen family genes
Yujun Zhang, Bingyu Mao
2010, 37(9): 637-645. doi: 10.1016/S1673-8527(09)60082-5
Abstract (158) HTML PDF (0)
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The secreted Wnt signaling inhibitor Dickkopf1 (Dkk1) plays key role in vertebrate head induction. Its receptor Kremen synergizes with Dkk1 in Wnt inhibition. Here we have carried out expression and functional studies of the Dkk and Kremen genes in amphioxus (Branchiostoma belcheri). During embryoni...
Atp4b promoter directs the expression of Cre recombinase in gastric parietal cells of transgenic mice
Zengming Zhao, Ning Hou, Yanxun Sun, Yan Teng, Xiao Yang
2010, 37(9): 647-652. doi: 10.1016/S1673-8527(09)60083-7
Abstract (126) HTML PDF (5)
Abstract:
Parietal cells are one of the largest epithelium cells of the mucous membrane of the stomach that secrete hydrochloric acid. To study the function of gastric parietal cells during gastric epithelium homeostasis, we generated a transgenic mouse line, namely, Atp4b-Cre, in which the expression of Cre ...