Wg signaling in Drosophila heart development as a pioneering model

Xiushan Wu

doi:10.1016/S1673-8527(09)60079-5

Volume 37 Issue 9

Sep. 2010

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Article Navigation > Journal of Genetics and Genomics > 2010 > 37(9): 593-603

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Wg signaling in Drosophila heart development as a pioneering model

doi: 10.1016/S1673-8527(09)60079-5

Xiushan Wu

The Center for Heart Development, Key Lab of MOE for Developmental Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, China

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Corresponding author: E-mail address: xiushanwu@yahoo.com (Xiushan Wu)
Received Date: 2010-04-04
Accepted Date: 2010-07-03
Rev Recd Date: 2010-06-12

Available Online: 2010-10-07

Publish Date: 2010-09-20

Abstract

Abstract

The heart is one of the first functional embryonic organs occurring during development. The fundamental developmental processes and genes involved in cardiogenesis are conserved between the invertebrates and vertebrates. In the past fifteen years, one of signaling pathways that has been best characterized in heart development in both invertebrates and vertebrates is the Wg/Wnt signaling pathways. Since our discovery of the Wg signaling required for the early heart development inDrosophila, the past fifteen years have witnessed tremendous progress in the understanding of specific Wnt signaling pathways in vertebrate cardiogenesis. This review will summarize the current state of knowledge of Wg signaling transduction in Drosophila heart development, which will benefit our understanding of vertebrate cardiogenesis and human congenital malformations.
- heart development,
- Wg/Wnt signaling,
- pioneering model,
- congenital malformations

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References

[1]	Axelrod, J.D., Matsuno, K., Artavanis-Tsakonas, S. et al. Interaction between Wingless and Notch signaling pathways mediated by Dishevelled Science, 271 (1996),pp. 1826-1832
[2]	Bilic, J., Huang, Y.L., Davidson, G. et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation Science, 316 (2007),pp. 1619-1622
[3]	Bryantsev, A.L., Cripps, R.M. Biochim. Biophys. Acta, 1789 (2009),pp. 343-353
[4]	Cavallo, R.A., Cox, R.T., Moline, M.M. et al. Nature, 395 (1998),pp. 604-608
[5]	Chen, X., Shevtsov, S.P., Hsich, E. et al. The β-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy Mol. Cell. Biol., 26 (2006),pp. 4462-4473
[6]	Christodoulides, C., Laudes, M., Cawthorn, W.P. et al. The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis J. Cell Sci., 119 (2006),pp. 2613-2620
[7]	Clevers, H. Wnt/beta-catenin signaling in development and disease Cell, 127 (2006),pp. 469-480
[8]	Cohen, E.D., Tian, Y., Morrisey, E.E. Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis, and progenitor self-renewal Development, 135 (2008),pp. 789-798
[9]	Cong, F., Schweizer, L., Varmus, H. Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP Development, 131 (2004),pp. 5103-5115
[10]	Croce, C., McClay, D.R., Vincan, E.
[11]	Davidson, B. Ciona intestinalis as a model for cardiac development Semin. Cell. Dev. Biol., 18 (2007),pp. 16-26
[12]	Eisenberg, L.M., Eisenberg, C.A. Wnt signal transduction and the formation of the myocardium Dev. Biol., 293 (2006),pp. 305-315
[13]	Fang, M., Li, J., Blauwkamp, T. et al. EMBO J., 25 (2006),pp. 2735-2745
[14]	Hamblet, N.S., Lijam, N., Ruiz-Lozano, P. et al. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure Development, 129 (2002),pp. 5827-5838
[15]	Hartenstein, V., Mandal, L. The blood/vascular system in a phylogenetic perspective Bioessays, 28 (2006),pp. 1203-1210
[16]	Hoffmans, R., Stadeli, R., Basler, K. Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin Curr. Biol., 15 (2005),pp. 1207-1211
[17]	Joziasse, I.C., van de Smagt, J.J., Smith, K. et al. Genes in congenital heart disease: atrioventricular valve formation Basic Res. Cardiol., 103 (2008),pp. 216-227
[18]	Kawano, Y., Kypta, R. Secreted antagonists of the Wnt signaling pathway J Cell Sci., 116 (2003),pp. 2627-2634
[19]	Kikuchi, A., Yamamoto, H., Kishida, S. Multiplicity of the interactions of Wnt proteins and their receptors Cell Signal., 19 (2007),pp. 659-671
[20]	Koyanagi, M., Haendeler, J., Badorff, C. et al. Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells J. Biol. Chem., 280 (2005),pp. 16838-16842
[21]	Krishnan, V., Bryant, H.U., Macdougald, O.A. Regulation of bone mass by Wnt signaling J. Clin. Invest., 116 (2006),pp. 1202-1209
[22]	Kühl, M., Sheldahl, L.C., Park, M. et al. Trends Genet., 16 (2000),pp. 279-283
[23]	Lee, H.H., Frasch, M. Development, 127 (2000),pp. 5497-5508
[24]	Lee, H.H., Frasch, M. Development, 132 (2005),pp. 1429-1442
[25]	Lickert, H., Kutsch, S., Kanzler, B. et al. Formation of multiple hearts in mice following deletion of β-catenin in the embryonic endoderm Dev. Cell, 3 (2002),pp. 171-181
[26]	Liu, Y., Rubin, B., Bodine, P.V. et al. Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase J. Cell Biochem., 105 (2008),pp. 497-502
[27]	Lockwood, W.K., Bodmer, R. Mech. Dev., 114 (2002),pp. 13-26
[28]	Logan, C.Y., Nusse, R. The Wnt signaling pathway in development and disease Annu. Rev. Cell Dev. Biol., 20 (2004),pp. 781-810
[29]	Marvin, M.J., Di Rocco, G., Gardiner, A. et al. Inhibition of Wnt activity induces heart formation from posterior mesoderm Genes Dev., 15 (2001),pp. 316-327
[30]	Matsui, T., Raya, A., Kawakami, Y. et al. Non-canonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development Genes Dev., 19 (2005),pp. 164-175
[31]	Moon, R.T., Kohn, A.D., De Ferrari, G.V. et al. WNT and beta-catenin signaling: diseases and therapies Nat. Rev. Genet., 5 (2004),pp. 691-701
[32]	Naito, A.T., Shiojima, I., Akazawa, H. et al. Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis Proc. Natl. Acad. Sci. USA, 103 (2006),pp. 19812-19817
[33]	Noordermeer, J., Klingensmith, J., Perrimon, N. et al. Nature, 367 (1994),pp. 80-83
[34]	Nusse, R., Brown, A., Papkoff, J. et al. A new nomenclature for int-1 and related genes: the Wnt gene family Cell, 64 (1991),p. 231
[35]	Ocorr, K., Perrin, L., Lim, H.Y. et al. Trends Cardiovasc. Med., 17 (2007),pp. 177-182
[36]	Pandur, P., Lasche, M., Eisenberg, L.M. et al. Wnt-11 activation of a non-canonical Wnt signaling pathway is required for cardiogenesis Nature, 418 (2002),pp. 636-641
[37]	Park, M., Wu, X., Golden, K. et al. Dev. Biol., 177 (1996),pp. 104-116
[38]	Phillips, H.M., Murdoch, J.N., Chaudhry, B. et al. Circ. Res., 96 (2005),pp. 292-299
[39]	Pongracz, J.E., Stockley, R.A. Wnt signaling in lung development and diseases Respir. Res., 7 (2006),pp. 15-24
[40]	Reya, T., Clevers, H. Wnt signaling in stem cells and cancer Nature, 434 (2005),pp. 843-850
[41]	Rijsewijk, F., Schuermann, M., Wagenaar, E. et al. Cell, 50 (1987),pp. 649-657
[42]	Terami, H., Hidaka, K., Katsumata, T. et al. Wnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes Biochem. Biophys. Res. Comm., 25 (2004),p. 968
[43]	Tzahor, E. Wnt/beta-catenin signaling and cardiogenesis: timing does matter Dev. Cell, 13 (2007),pp. 10-13
[44]	Ueno, S., Weidinger, G., Osugi, T. et al. Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells Proc. Natl. Acad. Sci. USA, 104 (2007),pp. 9685-9690
[45]	van de Schans, V.A., Smits, J.F., Blankesteijn, W.M. The Wnt/frizzled pathway in cardiovascular development and disease: friend or foe? Eur. J. Pharmacol., 585 (2008),pp. 338-345
[46]	van Es, J.H., Barker, N., Clevers, H. You Wnt some, you lose some: oncogenes in the Wnt signaling pathway Curr. Opin. Genet. Dev., 13 (2003),pp. 28-33
[47]	Vertino, A.M., Taylor-Jones, J.M., Longo, K.A. et al. Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts Mol. Biol. Cell, 16 (2005),pp. 2039-2048
[48]	Vijayaragavan, K., Bhatia, M. Early cardiac development: a Wnt beat away Proc. Natl. Acad. Sci. USA, 104 (2007),pp. 9549-9550
[49]	Wallingford, J.B., Habas, R. The developmental biology of dishevelled: an enigmatic protein govering cell fate and cell polarity Development, 132 (2005),pp. 4421-4436
[50]	Widelitz, R. Wnt signaling through canonical and non-canonical pathways: recent progress Growth Factors, 23 (2005),pp. 111-116
[51]	Wu, X.
[52]	Wu, X.
[53]	Wu, X., Golden, K., Bodmer, R. Dev. Biol., 169 (1995),pp. 619-628
[54]	Yanagawa, S., Leeuwen, F., Wodarz, A. et al. Genes Dev., 9 (1995),pp. 1087-1097
[55]	Zeitouni, B., Sénatore, S., Séverac, D. et al. PLoS Genet., 3 (2007),pp. 1907-1921
[56]	Zmojdzian, M, Da Ponte, J.P., Jagla, K. Proc. Natl. Acad. Sci. USA, 105 (2008),pp. 2475-2480