Journal of Genetics and Genomics

Sensing of membrane tensions: the pleiotropic functions of OSCA/TMEM63 mechanosensitive ion channels

Bo Yu, Alex Costa, Yang Zhao

2024, 51(6): 579-582. doi: 10.1016/j.jgg.2024.02.002

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Genetic and molecular mechanisms of reproductive isolation in the utilization of heterosis for breeding hybrid rice

Chaolong Wang, Xiaowen Yu, Jian Wang, Zhigang Zhao, Jianmin Wan

2024, 51(6): 583-593. doi: 10.1016/j.jgg.2024.01.007

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Heterosis, also known as hybrid vigor, is commonly observed in rice crosses. The hybridization of rice species or subspecies exhibits robust hybrid vigor, however, the direct harnessing of this vigor is hindered by reproductive isolation. Here, we review recent advances in the understanding of the m...

The non-canonical poly(A) polymerase FAM46C promotes erythropoiesis

Ke Yang, Tianqi Zhu, Jiaying Yin, Qiaoli Zhang, Jing Li, Hong Fan, Gaijing Han, Weiyin Xu, Nan Liu, Xiang Lv

2024, 51(6): 594-607. doi: 10.1016/j.jgg.2024.02.003

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The post-transcriptional regulation of mRNA is a crucial component of gene expression. The disruption of this process has detrimental effects on the normal development and gives rise to various diseases. Searching for novel post-transcriptional regulators and exploring their roles are essential for ...

Fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement: insights into COVID-19 pathogenesis

Han Du, Zhongtao Du, Liang Wang, Hong Wang, Mingjun Jia, Chunge Zhang, Yun Liu, Cheng Zhang, Ya Zhang, Ruifeng Zhang, Shuang Zhang, Ning Zhang, Zhenghai Ma, Chen Chen, Wenjun Liu, Hui Zeng, George F. Gao, Xiaotong Hou, Yuhai Bi

2024, 51(6): 608-616. doi: 10.1016/j.jgg.2024.02.007

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often leads to pulmonary complications. Cardiovascular sequelae, including myocarditis and heart failure, have also been reported. Here, the study presents two fulminant myocarditis cases infected by SARS-CoV-2 exhibiting remarka...

ERβ-activated LINC01018 promotes endometriosis development by regulating the CDC25C/CDK1/CyclinB1 pathway

Ruihui Lu, Jingwen Zhu, Xin Li, Cheng Zeng, Yan Huang, Chao Peng, Yingfang Zhou, Qing Xue

2024, 51(6): 617-629. doi: 10.1016/j.jgg.2023.12.012

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Endometriosis refers to as an estrogen-dependent disease. Estrogen receptor β (ERβ), the main estrogen receptor subtype which is encoded by the estrogen receptor 2 (ESR2) gene, can mediate the action of estrogen in endometriosis. Although selective estrogen receptor modulators can target the ERβ, th...

Aagab is required for zebrafish larval development by regulating neural activity

Shihui Ding, Tursunjan Aziz, Anming Meng, Shunji Jia

2024, 51(6): 630-641. doi: 10.1016/j.jgg.2024.01.003

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Clathrin-mediated endocytosis has been implicated in various physiological processes, including nutrient uptake, signal transduction, synaptic vesicle recycling, maintenance of cell polarity, and antigen presentation. Despite prior knowledge of its importance as a key regulator in promoting clathrin...

Reconstruct recent multi-population migration history by using identical-by-descent sharing

Wenxiao Zhang, Kai Yuan, Ru Wen, Haifang Li, Xumin Ni

2024, 51(6): 642-651. doi: 10.1016/j.jgg.2024.02.006

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Identical-by-descent (IBD) is a fundamental genomic characteristic in population genetics and has been widely used for population history reconstruction. However, limited by the nature of IBD, which could only capture the relationship between two individuals/haplotypes, existing IBD-based history in...

RNAirport: a deep neural network-based database characterizing representative gene models in plants

Sitao Zhu, Shu Yuan, Ruixia Niu, Yulu Zhou, Zhao Wang, Guoyong Xu

2024, 51(6): 652-664. doi: 10.1016/j.jgg.2024.03.004

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A 5′-leader, known initially as the 5′-untranslated region, contains multiple isoforms due to alternative splicing (aS) and alternative transcription start site (aTSS). Therefore, a representative 5′-leader is demanded to examine the embedded RNA regulatory elements in controlling translation effici...

Genetic basis of geographical differentiation, breeding selection, domestication effects, and breeding application for TaJAZ1 in wheat

Botao Ye, Yangyang Liu, Ziying Wang, Liping Shen, Changbin Yin, Kuocheng Shen, Jiaqiang Sun, Xiaowan Xu, Mengjing Sun, Jianhui Wu, Zhonghu He, Xuchang Yu, Fei Lu, Yuanfeng Hao, Zifeng Guo

2024, 51(6): 665-668. doi: 10.1016/j.jgg.2024.01.004

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Caudal hematopoietic tissue supports definitive erythrocytes via epoa and is dispensable for definitive neutrophils

Zhujuan Huang, Yongtai Xu, Zhongkai Qiu, Yunyun Jiang, Jiaye Wu, Qing Lin, Sicong He, Jianan Y. Qu, Jiahao Chen, Jin Xu

2024, 51(6): 669-672. doi: 10.1016/j.jgg.2024.02.001

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TMEM63B regulates postnatal development of cochlear sensory epithelia via thyroid hormone signaling

Chang Ye, Tian-Zi Zhang, Yan-Yu Zang, Yun Stone Shi, Guoqiang Wan

2024, 51(6): 673-676. doi: 10.1016/j.jgg.2023.12.006

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2024 Vol. 51, No. 6