5.9
CiteScore
5.9
Impact Factor

2020 Vol. 47, No. 1

Display Method:
Review
Engineering T cells for immunotherapy of primary human hepatocellular carcinoma
Leidy D. Caraballo Galva, Lun Cai, Yanxia Shao, Yukai He
2020, 47(1): 1-15. doi: 10.1016/j.jgg.2020.01.002
Abstract (179) HTML PDF (6)
Abstract:
Liver cancers, majority of which are primary hepatocellular carcinoma (HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over the last few years...
Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
Qianru Huang, Xu Liu, Yujia Zhang, Jingyao Huang, Dan Li, Bin Li
2020, 47(1): 17-26. doi: 10.1016/j.jgg.2019.11.011
Abstract (110) HTML PDF (2)
Abstract:
Regulatory T (Treg) cells, a subtype of immunosuppressive CD4+ T cells, are vital for maintaining immune homeostasis in healthy people. Forkhead box protein P3 (FOXP3), a member of the forkhead-winged-helix family, is the pivotal transcriptional factor of Treg cells. The expression, post-translation...
Structural and immunogenomic insights into B-cell receptor activation
Yangyang Feng, Yu Wang, Shaocun Zhang, Kabeer Haneef, Wanli Liu
2020, 47(1): 27-35. doi: 10.1016/j.jgg.2019.12.003
Abstract (105) HTML PDF (3)
Abstract:
B cells express B-cell receptors (BCRs) which recognize antigen to trigger signaling cascades for B-cell activation and subsequent antibody production. BCR activation has a crucial influence on B-cell fate. How BCR is activated upon encountering antigen remains to be solved, although tremendous prog...
Original Research
Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted primordial germ cells
Fenghua Zhang, Xianmei Li, Mudan He, Ding Ye, Feng Xiong, Golpour Amin, Zuoyan Zhu, Yonghua Sun
2020, 47(1): 37-47. doi: 10.1016/j.jgg.2019.12.004
Abstract (128) HTML PDF (3)
Abstract:
The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology has been widely utilized for knocking out genes involved in various biological processes in zebrafish. Despite this technology is efficient for generating different mutations, one of the main drawbacks is low surv...
Genome-wide evolution analysis reveals low CpG contents of fast-evolving genes and identifies antiviral microRNAs
Wenhong Zu, Hang Zhang, Xun Lan, Xu Tan
2020, 47(1): 49-60. doi: 10.1016/j.jgg.2019.12.001
Abstract (107) HTML PDF (2)
Abstract:
Noncoding RNAs (ncRNAs) play important roles in many biological processes and provide materials for evolutionary adaptations beyond protein-coding genes, such as in the arms race between the host and pathogen. However, currently, a comprehensive high-resolution analysis of primate genomes that inclu...
Letter to the Editor
Arabidopsis EED1 encoding a plant-specific nuclear protein is essential for early embryogenesis
Mai Yang, Chun Yan, Megan Griffith, Jinping Zhao, Yongbiao Zhang, Daoxin Xie, Jianbin Yan
2020, 47(1): 61-64. doi: 10.1016/j.jgg.2019.12.005
Abstract (142) HTML PDF (7)
Abstract:
Rapid and specific isolation of intact mitochondria from Arabidopsis leaves
Lilan Luo, Yajun He, Qian Xu, Wenhui Lyu, Jijun Yan, Peiyong Xin, Dahan Zhang, Jinfang Chu, Jiayang Li, Hong Yu
2020, 47(1): 65-68. doi: 10.1016/j.jgg.2020.01.001
Abstract (99) HTML PDF (3)
Abstract: