Structural and immunogenomic insights into B-cell receptor activation

Yangyang Feng; Yu Wang; Shaocun Zhang; Kabeer Haneef; Wanli Liu

doi:10.1016/j.jgg.2019.12.003

Volume 47 Issue 1

Jan. 2020

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Article Navigation > Journal of Genetics and Genomics > 2020 > 47(1): 27-35

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Structural and immunogenomic insights into B-cell receptor activation

doi: 10.1016/j.jgg.2019.12.003

MOE Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Beijing Key Lab for Immunological Research on Chronic Diseases, Institute for Immunology, Tsinghua University, Beijing, 100084, China

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Corresponding author: E-mail address: liulab@tsinghua.edu.cn (Wanli Liu)
Publish Date: 2020-01-25

Abstract

Abstract

B cells express B-cell receptors (BCRs) which recognize antigen to trigger signaling cascades for B-cell activation and subsequent antibody production. BCR activation has a crucial influence on B-cell fate. How BCR is activated upon encountering antigen remains to be solved, although tremendous progresses have been achieved in the past few years. Here, we summarize the models that have been proposed to explain BCR activation, including the cross-linking model, the conformation-induced oligomerization model, the dissociation activation model, and the conformational change model. Especially, we elucidate the partially resolved structures of antibodies and/or BCRs by far and discusse how these current structural and further immunogenomic messages and more importantly the future studies may shed light on the explanation of BCR activation and the relevant diseases in the case of dysregulation.
- B-cell receptor,
- B-cell activation,
- BCR structure,
- Immunogenomics

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References(107)

References

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