9.9
CiteScore
7.1
Impact Factor

2011 Vol. 38, No. 7

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Research article
Recent progress in the genetics of generalized vitiligo
Richard A. Spritz
2011, 38(7): 271-278. doi: 10.1016/j.jgg.2011.05.005
Abstract (81) HTML PDF (0)
Abstract:
Vitiligo is an acquired disease characterized principally by patchy depigmentation of skin and overlying hair. Generalized vitiligo (GV), the predominant form of the disorder, results from autoimmune loss of melanocytes from affected regions. GV is a “complex trait”, inherited in a non-Mendelian pol...
Evolutionary rewiring and reprogramming of bacterial transcription regulation
Li Wang, Fang-Fang Wang, Wei Qian
2011, 38(7): 279-288. doi: 10.1016/j.jgg.2011.06.001
Abstract (92) HTML PDF (0)
Abstract:
Rewiring and reprogramming of transcriptional regulation took place during bacterial speciation. The mechanistic alterations among transcription factors, cis-regulatory elements and target genes confer bacteria novel ability to adapt to stochastic environmental changes. This process is critical to t...
Establishment of novel embryonic stem (ES) cell lines from OG2/rtTA blastocysts
Hui Yao, Yonghua Jiang, Yu Zhang, Wenqiang Liu, Bo Huang, Xiaodong Wang, Shaorong Gao
2011, 38(7): 289-295. doi: 10.1016/j.jgg.2011.05.007
Abstract (91) HTML PDF (1)
Abstract:
Embryonic stem (ES) cells derived from the pre-implantation blastocyst-stage embryos have been widely used to investigate the molecular events determining pluripotency and cell lineage differentiation. As the first discovered ES-specific transcription factor, Oct4 has been considered as the core plu...
Increased complexity of gene structure and base composition in vertebrates
Ying Wu, Huizhong Yuan, Shengjun Tan, Jian-Qun Chen, Dacheng Tian, Haiwang Yang
2011, 38(7): 297-305. doi: 10.1016/j.jgg.2011.06.004
Abstract (87) HTML PDF (0)
Abstract:
How the structure and base composition of genes changed with the evolution of vertebrates remains a puzzling question. Here we analyzed 895 orthologous protein-coding genes in six multicellular animals: human, chicken, zebrafish, sea squirt, fruit fly, and worm. Our analyses reveal that many gene re...
The alkaline tolerance in Arabidopsis requires stabilizing microfilament partially through inactivation of PKS5 kinase
Juntao Liu, Yan Guo
2011, 38(7): 307-313. doi: 10.1016/j.jgg.2011.05.006
Abstract (76) HTML PDF (0)
Abstract:
High soil pH is harmful to plant growth and development. The organization and dynamics of microfilament (MF) cytoskeleton play important roles in the plant anti-alkaline process. In the previous study, we determined that alkaline stress induces a signal that triggers MF dynamics-dependent root growt...
Use of methylation filtration and C0t fractionation for analysis of genome composition and comparative genomics in bread wheat
Rajib Bandopadhyay, Sachin Rustgi, Rajat Kanti Chaudhuri, Paramjit Khurana, Jitendra Paul Khurana, Akhilesh Kumar Tyagi, Harindra Singh Balyan, Andreas Houben, Pushpendra Kumar Gupta
2011, 38(7): 315-325. doi: 10.1016/j.jgg.2011.06.003
Abstract (73) HTML PDF (0)
Abstract:
We investigated the compositional and structural differences in sequences derived from different fractions of wheat genomic DNA obtained using methylation filtration and C0t fractionation. Comparative analysis of these sequences revealed large compositional and structural variations in terms of GC c...