GCH1 contributes to high-altitude adaptation in Tibetans by regulating blood nitric oxide

doi: 10.1016/j.jgg.2025.04.005

• Yongbo Guo ^a,b , 
• Wangshan Zheng ^a,b,c , 
• Tian Yue ^a,b , 
• Baimakangzhuo ^d , 
• Xuebin Qi ^e , 
• Kai Liu ^a , 
• Liya Li ^a , 
• Yaoxi He ^a     , 
• Bing Su ^a,f    

•  

  a. State Key Laboratory of Genetic Evolution and Animal Models, and Yunnan Key Laboratory of Integrative Anthropology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China;

•  

  b. Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100101, China;

•  

  c. School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, China;

•  

  d. High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa, Xizang 850000, China;

•  

  e. State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650223, China;

•  

  f. Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 650223, China