Resolving the spatial and cellular architecture of intra-tumor heterogeneity by multi-region dissection of lung adenocarcinoma

doi: 10.1016/j.jgg.2025.02.006

• Song Mei ^a,b , 
• Xiaolei Wang ^c , 
• Mengmeng Zhao ^d , 
• Qing Huang ^e , 
• Yixuan Huang ^f , 
• Mingming Su ^f , 
• Xinlei Zhang ^f , 
• Xu Wang ^g , 
• Xueyu Hao ^a , 
• Tianning Wang ^d , 
• Yanhua Wu ^h , 
• Yuanhui Ma ^c , 
• Jingnan Wang ⁱ , 
• Peng Zhang ^a     , 
• Yan Zheng ^d    

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  a. Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Rare Disease Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China;

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  b. Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;

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  c. Department of Pathology, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong 250100, China;

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  d. Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, China;

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  e. Department of Thoracic Surgery, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong 250100, China;

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  f. Beijing ClouDNA Technology Co., Ltd., Beijing 100080, China;

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  g. School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, Fujian 350122, China;

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  h. Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong 250100, China;

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  i. Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, China