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Volume 51 Issue 7
Jul.  2024
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Article Contents

Genetic mapping of plasma proteome on brain structure

doi: 10.1016/j.jgg.2024.03.017
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This work is supported by the National Natural Science Foundation of China (U21A20427, 82103826, and 92374112) and Research Program of Westlake Laboratory of Life Sciences and Biomedicine (202208012).

  • Received Date: 2024-02-27
  • Accepted Date: 2024-03-31
  • Rev Recd Date: 2024-03-28
  • Available Online: 2025-06-06
  • Publish Date: 2024-04-10
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  • Eckenstaler, R., Hauke, M., Benndorf, R.A., 2022. A current overview of RhoA, RhoB, and RhoC functions in vascular biology and pathology. Biochem. Pharmacol. 206, 115321.
    Elliott, L.T., Sharp, K., Alfaro-Almagro, F., Shi, S., Miller, K.L., Douaud, G., Marchini, J., Smith, S.M., 2018. Genome-wide association studies of brain imaging phenotypes in UK Biobank. Nature 562, 210-216.
    Ferkingstad, E., Sulem, P., Atlason, B.A., Sveinbjornsson, G., Magnusson, M.I., Styrmisdottir, E.L., Gunnarsdottir, K., Helgason, A., Oddsson, A., Halldorsson, B.V., et al., 2021. Large-scale integration of the plasma proteome with genetics and disease. Nat. Genet. 53, 1712-1721.
    Folkersen, L., Gustafsson, S., Wang, Q., Hansen, D.H., Hedman, A, K., Schork, A., Page, K., Zhernakova, D.V., Wu, Y., Peters, J., et al., 2020. Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals. Nat. Metab. 2, 1135-1148.
    Grasby, K.L., Jahanshad, N., Painter, J.N., Colodro-Conde, L., Bralten, J., Hibar, D.P., Lind, P.A., Pizzagalli, F., Ching, C.R.K., McMahon, M.A.B., et al., 2020. The genetic architecture of the human cerebral cortex. Science 367.
    Koprulu, M., Carrasco-Zanini, J., Wheeler, E., Lockhart, S., Kerrison, N.D., Wareham, N.J., Pietzner, M., Langenberg, C., 2023. Proteogenomic links to human metabolic diseases. Nat. Metab. 5, 516-528.
    Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S.J., Di Lisi, R., Sandri, C., Zhao, J., et al., 2007. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 6, 458-471.
    McConaghy, J.R., McGuirk, R., 2019. Amblyopia: Detection and Treatment. Am. Fam. Physician. 100, 745-750.
    Pietzner, M., Wheeler, E., Carrasco-Zanini, J., Cortes, A., Koprulu, M., Worheide, M.A., Oerton, E., Cook, J., Stewart, I.D., Kerrison, N.D., et al., 2021. Mapping the proteo-genomic convergence of human diseases. Science 374, eabj1541.
    Pradhan, R., Yadav, S.K., Prem, N.N., Bhagel, V., Pathak, M., Shekhar, S., Gaikwad, S., Dwivedi, S.N., Bal, C.S., Dey, A.B., et al., 2020. Serum FOXO3A: a ray of hope for early diagnosis of Alzheimer's disease. Mech. Ageing Dev. 190, 111290.
    Renault, V.M., Rafalski, V.A., Morgan, A.A., Salih, D.A., Brett, J.O., Webb, A.E., Villeda, S.A., Thekkat, P.U., Guillerey, C., Denko, N.C., et al., 2009. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell 5, 527-539.
    Smith, S.M., Douaud, G., Chen, W., Hanayik, T., Alfaro-Almagro, F., Sharp, K., Elliott, L.T., 2021. An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank. Nat. Neurosci. 24, 737-745.
    Suhre, K., Arnold, M., Bhagwat, A.M., Cotton, R.J., Engelke, R., Raffler, J., Sarwath, H., Thareja, G., Wahl, A., DeLisle, R.K., et al., 2017. Connecting genetic risk to disease end points through the human blood plasma proteome. Nat. Commun. 8, 14357.
    Sun, B., Maranville, J.C., Peters, J.E., Stacey, D., Butterworth, A.S., 2018. Genomic atlas of the human plasma proteome. Nature 558, 73-79.
    Wang, Y., Lin, Y., Wang, L., Zhan, H., Luo, X., Zeng, Y., Wu, W., Zhang, X., Wang, F., 2020. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice. Aging (Albany NY) 12, 20862-20879.
    Yao, C., Chen, G., Song, C., Keefe, J., Mendelson, M., Huan, T., Sun, B.B., Laser, A., Maranville, J.C., Wu, H., et al., 2018. Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease. Nat. Commun. 9, 3268.
    Zhao, B., Li, T., Yang, Y., Wang, X., Luo, T., Shan, Y., Zhu, Z., Xiong, D., Hauberg, M.E., Bendl, J., et al., 2021. Common genetic variation influencing human white matter microstructure. Science 372, eabf3736.
    Zhao, H., Rasheed, H., Noest, T.H., Cho, Y., Liu, Y., Bhatta, L., Bhattacharya, A., Hemani, G., Davey Smith, G., Brumpton, B.M., et al., 2022. Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases. Cell Genom. 2, None.
    Zhao, J.H., Stacey, D., Eriksson, N., Macdonald-Dunlop, E., Hedman, A, K., Kalnapenkis, A., Enroth, S., Cozzetto, D., Digby-Bell, J., Marten, J., et al., 2023. Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets. Nat. Immunol. 24, 1540-1551.
    Zheng, J., Haberland, V., Baird, D., Walker, V., Haycock, P.C., Hurle, M.R., Gutteridge, A., Erola, P., Liu, Y., Luo, S., et al., 2020. Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases. Nat. Genet. 52, 1122-1131.
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