Emerging functions of tRNA modifications in mRNA translation and diseases

Lu Wang; Shuibin Lin

doi:10.1016/j.jgg.2022.10.002

Volume 50 Issue 4

Apr. 2023

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Emerging functions of tRNA modifications in mRNA translation and diseases

doi: 10.1016/j.jgg.2022.10.002

Lu Wang^a,b,
Shuibin Lin^b,c

a. Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, China;
b. Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
c. State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510080, China

Funds:

The work was funded by the National Natural Science Foundation of China (81922052, 81974435, and 81772999), a Distinguished Young Scholars grant from the Natural Science Foundation of Guangdong (2019B151502011), and the Guangzhou People's Livelihood Science and Technology Project (201903010006).

Received Date: 2022-06-04
Accepted Date: 2022-10-17
Rev Recd Date: 2022-10-17
Publish Date: 2023-04-30

Abstract

Abstract

tRNAs are essential modulators that recognize mRNA codons and bridge amino acids for mRNA translation. The tRNAs are heavily modified, which are essential for forming a complex secondary structure that facilitates codon recognition and mRNA translation. In recent years, studies have identified the regulatory roles of tRNA modifications in mRNA translation networks. Misregulation of tRNA modifications is closely related to the progression of developmental diseases and cancers. In this review, we summarize the tRNA biogenesis process and then discuss the effects and mechanisms of tRNA modifications on tRNA processing and mRNA translation. Finally, we provide a comprehensive overview of the physiological and pathological functions of tRNA modifications, focusing on diseases including cancers.
- tRNA modification,
- tRNA processing,
- Translation,
- Cancer,
- Developmental diseases

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References(131)

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