Absence of <i>Serpinb6a</i> causes progressive hair cell apoptosis and hearing loss in mice

Cheng Cheng; Jieyu Qi; Liyan Zhang; He Li; Jie Lu; Siyu Li; Zhong Zhang; Yue Qiu; Chen Zhang; Lulu Jiang; Chaorong Yu; Xia Gao; Phillip I. Bird; Renjie Chai

doi:10.1016/j.jgg.2022.08.006

Volume 50 Issue 2

Feb. 2023

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Article Navigation > Journal of Genetics and Genomics > 2023 > 50(2): 122-125

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Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice

doi: 10.1016/j.jgg.2022.08.006

Cheng Cheng^1,2,
Jieyu Qi³,
Liyan Zhang³,
He Li⁴,
Jie Lu⁵,
Siyu Li⁶,
Zhong Zhang⁷,
Yue Qiu⁸,
Chen Zhang⁹,
Lulu Jiang¹⁰,
Chaorong Yu¹⁰,
Xia Gao^11,12,
Phillip I. Bird¹³,
Renjie Chai^{15,16,17,14,18}

1. Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), No.321 Zhongshan Road, Nanjing, Jiangsu 210008, China;
2. Research Institute of Otolaryngology, No.321 Zhongshan Road, Nanjing, Jiangsu 210008, China;
3. State Key Laboratory of Bioelectronics, School of Life Sciences and Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, Jiangsu 210096, China;
4. Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, China;
5. Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225009, China;
6. Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), No.321 Zhongshan Road, Nanjing, Jiangsu 210008, China;
7. State Key Laboratory of Bioelectronics, School of Life Sciences and Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, Jiangsu 210096, China;
8. Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), No.321 Zhongshan Road, Nanjing, Jiangsu 210008, China;
9. Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing 100069, China;
10. Suzhou Otovia Therapeutics Inc., Suzhou, Jiangsu 215021, China;
11. Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), No.321 Zhongshan Road, Nanjing, Jiangsu 210008, China;
12. Research Institute of Otolaryngology, No.321 Zhongshan Road, Nanjing, Jiangsu 210008, China;
13. Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia;
14. Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing 100069, China;
15. State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, Jiangsu 210009, China;
16. Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China;
17. Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China;
18. Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing 100086, China

Funds:

D Program of China (2017YFA0105201, 2021YFA1101300, 2020YFA0112503), the Strategic Priority Research Program of the Chinese Academy of Science (XDA16010303), the National Natural Science Foundation of China (82030029, 81970882, 81900941, 82171144, 82192862, 81970884, 81771019), the Natural Science Foundation from Jiangsu Province (BE2019711, BK20190121), the China Postdoctoral Science Foundation (2020M681555), the Outstanding Youth Program of Nanjing Municipal Health Commission (JQX20003), the Science and Technology Department of Sichuan Province (2021YFS0371), the Shenzhen Fundamental Research Program (JCYJ20190814093401920, JCYJ20210324125608022), and the Open Research Fund of State Key Laboratory of Genetic Engineering, Fudan University (SKLGE-2109). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

This work was supported by grants from the National Key R&

Received Date: 2022-08-19
Accepted Date: 2022-08-26
Rev Recd Date: 2022-08-26
Publish Date: 2022-09-08

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References(17)

References

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