Biogenesis of autophagosomes from the ERGIC membrane system

Yaping Han; Shulin Li; Liang Ge

doi:10.1016/j.jgg.2022.07.001

Volume 50 Issue 1

Jan. 2023

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Article Navigation > Journal of Genetics and Genomics > 2023 > 50(1): 3-6

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Biogenesis of autophagosomes from the ERGIC membrane system

doi: 10.1016/j.jgg.2022.07.001

The State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China

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We feel sorry that instead of citation for some of the original research articles, the related reviews are cited due to the space limitation. The work is funded by Beijing Natural Science Foundation (JQ20028), the National Natural Science Foundation of China (32130023, 91854114, 32061143009), Ministry of Science and Technology of the People's Republic of China (2019YFA0508602, 2021YFA0804802).

Received Date: 2022-04-26
Accepted Date: 2022-07-05
Rev Recd Date: 2022-07-01
Publish Date: 2023-01-28

Abstract

- ERGIC,
- COPII vesicle,
- Autophagosome biogenesis,
- Autophagy,
- ERES

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References(20)

References

Cui, Y., Parashar, S., Zahoor, M., Needham, P.G., Mari, M., Zhu, M., Chen, S., Ho, H.C., Reggiori, F., Farhan, H., et al., 2019. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science 365, 53-60

Ding, X., Jiang, X., Tian, R., Zhao, P., Li, L., Wang, X., Chen, S., Zhu, Y., Mei, M., Bao, S., et al., 2019. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy 15, 1774-1786

Farhan, H., Kundu, M.,Ferro-Novick, S., 2017. The link between autophagy and secretion:a story of multitasking proteins. Mol. Biol. Cell 28, 1161-1164

Gao, J., Kurre, R., Rose, J., Walter, S., Frohlich, F., Piehler, J., Reggiori, F.,Ungermann, C., 2020. Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex. EMBO Rep. 21, e50733

Ge, L., Melville, D., Zhang, M.,Schekman, R., 2013. The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. Elife 2, e00947

Ge, L., Zhang, M., Kenny, S.J., Liu, D., Maeda, M., Saito, K., Mathur, A., Xu, K.,Schekman, R., 2017. Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis. EMBO Rep. 18, 1586-1603

Ge, L., Zhang, M.,Schekman, R., 2014. Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment. Elife 3, e04135

Gui, X., Yang, H., Li, T., Tan, X., Shi, P., Li, M., Du, F.,Chen, Z.J., 2019. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567, 262-266

Jeong, Y.T., Simoneschi, D., Keegan, S., Melville, D., Adler, N.S., Saraf, A., Florens, L., Washburn, M.P., Cavasotto, C.N., Fenyo, D., et al., 2018. The ULK1-FBXW5-SEC23B nexus controls autophagy. Elife 7, e42253

Karanasios, E., Walker, S.A., Okkenhaug, H., Manifava, M., Hummel, E., Zimmermann, H., Ahmed, Q., Domart, M.C., Collinson, L.,Ktistakis, N.T., 2016. Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles. Nat. Commun. 7, 12420

Kumar, S., Javed, R., Mudd, M., Pallikkuth, S., Lidke, K.A., Jain, A., Tangavelou, K., Gudmundsson, S.R., Ye, C., Rusten, T.E., et al., 2021. Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes. Cell 184, 5950-5969

Lemus, L., Ribas, J.L., Sikorska, N.,Goder, V., 2016. An ER-localized SNARE protein is exported in specific COPII vesicles for autophagosome biogenesis. Cell Rep. 14, 1710-1722

Li, S., Yan, R., Xu, J., Zhao, S., Ma, X., Sun, Q., Zhang, M., Li, Y., Liu, J.G., Chen, L., et al., 2022. A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis. Cell Res. 32, 119-138

Nakatogawa, H., 2020. Mechanisms governing autophagosome biogenesis. Nat. Rev. Mol. Cell Biol. 21, 439-458

Stadel, D., Millarte, V., Tillmann, K.D., Huber, J., Tamin-Yecheskel, B.C., Akutsu, M., Demishtein, A., Ben-Zeev, B., Anikster, Y., Perez, F., et al., 2015. TECPR2 cooperates with LC3C to regulate COPII-dependent ER export. Mol. Cell. 60, 89-104

Wang, R., Miao, G., Shen, J.L., Fortier, T.M.,Baehrecke, E.H., 2022. ESCRT dysfunction compromises endoplasmic reticulum maturation and autophagosome biogenesis in Drosophila. Curr. Biol. 32, 1262-1274

Winer, H., Fraiberg, M., Abada, A., Dadosh, T., Tamim-Yecheskel, B.C.,Elazar, Z., 2018. Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins. Nat. Commun. 9, 3744

Yan, R., Chen, K., Wang, B., Xu, K., 2022. SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport. Dev. Cell 57, 512-525

Zheng J. F., Sun, Y.X., Liu L., Tao, X., Ge L., 2021. Diversified roles of the ER-Golgi intermediate compartment (in Chinese). Sci Sin Vitae. 1, 28-45

Zoppino, F.C., Militello, R.D., Slavin, I., Alvarez, C.,Colombo, M.I., 2010. Autophagosome formation depends on the small GTPase Rab1 and functional ER exit sites. Traffic. 11, 1246-1261

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