Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling

Baotong Zhang; Siyuan Xia; Mingcheng Liu; Xiawei Li; Shimin Shuai; Wei Tao; Yixiang Li; Jianping Jenny Ni; Wei Zhou; Lan Liao; Jianming Xu; Jin-Tang Dong

doi:10.1016/j.jgg.2021.11.013

Volume 49 Issue 6

Jun. 2022

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Article Navigation > Journal of Genetics and Genomics > 2022 > 49(6): 579-582

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Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling

doi: 10.1016/j.jgg.2021.11.013

1. Department of Human Cell Biology and Genetics, Southern University of Science and Technology School of Medicine, Shenzhen, Guangdong 518055, China;
2. Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA;
3. Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA;
4. Department of Human Cell Biology and Genetics, Southern University of Science and Technology School of Medicine, Shenzhen, Guangdong 518055, China;
5. Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA;
6. Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA;
7. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA;
8. Department of Human Cell Biology and Genetics, Southern University of Science and Technology School of Medicine, Shenzhen, Guangdong 518055, China;
9. Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA;
10. Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA

Funds:

We thank Dr. Anthea Hammond of Emory University for editing the manuscript. This work was supported by the grant JCYJ20200109141229255 from Science, Technology and Innovation Commission of Shenzhen Municipality. This work was also supported by grants R01CA171189 and R01CA193455 from the National Cancer Institute, National Institutes of Health. Research reported in this publication was supported in part by the Emory Integrated Genomics Core, Integrated Cellular Imaging Core Facility, Winship Research Pathology Core, and Transgenic Mouse and Gene Targeting Core of Emory University Winship Cancer Institute and NIH/NCI under award number P30CA138292.

Received Date: 2021-10-24
Accepted Date: 2021-11-29
Rev Recd Date: 2021-11-28
Publish Date: 2022-06-30

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