Nucleolar histone deacetylases HDT1, HDT2, and HDT3 regulate plant reproductive development

Yu Luo; Dong-Qiao Shi; Peng-Fei Jia; Yuan Bao; Hong-Ju Li; Wei-Cai Yang

doi:10.1016/j.jgg.2021.10.002

Volume 49 Issue 1

Jan. 2022

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Nucleolar histone deacetylases HDT1, HDT2, and HDT3 regulate plant reproductive development

doi: 10.1016/j.jgg.2021.10.002

a State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
b College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Funds:

This work was supported by funding from the National Natural Science Foundation of China (31991203 and 31870295).

Received Date: 2021-06-15
Accepted Date: 2021-10-14
Rev Recd Date: 2021-10-14
Publish Date: 2021-10-23

Abstract

Abstract

Nucleolus is a membrane-less organelle where ribosomes are assembled, and ribosomal RNAs (rRNAs) transcribed and processed. The assembled ribosomes composed of ribosomal proteins and rRNAs synthesize proteins for cell survival. In plants, the loss of nucleolar ribosomal proteins often causes gametophytically or embryonically lethality. The amount of rRNAs are under stringent regulation according to demand and partially switched off by epigenetic modifications. However, the molecular mechanism for the selective activation or silencing is still unclear, and the transcriptional coordination of rRNAs and ribosomal proteins is also unknown. Here, we report the critical role of three Arabidopsis nucleolar proteins HDT1, HDT2, and HDT3 in fertility and transcription of rDNAs and rRNA processing-related genes through histone acetylation. This study highlights the important roles of transcriptional repression of ribosome biogenesis-related genes for plant reproductive development.
- Histone deacetylase,
- rRNAs,
- Ribosome,
- Reproductive development

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References(63)

References

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