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Volume 49 Issue 1
Jan.  2022
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Article Navigation >  Journal of Genetics and Genomics  > 2022  >  49(1): 40-53

FGF8-mediated signaling regulates tooth developmental pace during odontogenesis

doi: 10.1016/j.jgg.2021.08.009
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    a Fujian Key Laboratory of Developmental and Neural Biology and Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian 350117, China;

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    b Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA

Funds:

This study was supported by the National Natural Science Foundation of China (81870739, 82001002, 81271102, 81771034) and the Natural Science Foundation of Fujian Province (2019J01281, 2020J01180).

  • Received Date: 2021-06-01
  • Accepted Date: 2021-08-11
  • Rev Recd Date: 2021-08-10
  • Publish Date: 2021-09-06
    Abstract
  • The developing human and mouse teeth constitute an ideal model system to study the regulatory mechanism underlying organ growth control since their teeth share highly conserved and well-characterized developmental processes, and their developmental tempo varies notably. In the current study, we manipulated heterogenous recombination between human and mouse dental tissues and demonstrated that the dental mesenchyme dominates the tooth developmental tempo and FGF8 could be a critical player during this developmental process. Forced activation of FGF8 signaling in the dental mesenchyme of mice promoted cell proliferation, prevented cell apoptosis via p38 and perhaps PI3K-Akt intracellular signaling, and impelled the transition of the cell cycle from G1- to S-phase in the tooth germ, resulting in the slowdown of the tooth developmental pace. Our results provide compelling evidence that extrinsic signals can profoundly affect tooth developmental tempo, and the dental mesenchymal FGF8 could be a pivotal factor in controlling the developmental pace in a non-cell-autonomous manner during mammalian odontogenesis.
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