Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling

Feifei Chen; Lei Guo; Jiehui Di; Man Li; Dong Dong; Dongsheng Pei

doi:10.1016/j.jgg.2021.07.017

Volume 48 Issue 12

Dec. 2021

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Article Navigation > Journal of Genetics and Genomics > 2021 > 48(12): 1091-1103

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Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling

doi: 10.1016/j.jgg.2021.07.017

a. Department of Cell Biology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China;
b. Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China

Funds:

This work was supported by grants from the National Natural Science Foundation of China (82072819, 81972377), Xuzhou Science and Technology Project (KC19024) and Jiangsu Research and Practice Innovation of Graduate Students (KYCX19-2213).

Received Date: 2021-01-17
Accepted Date: 2021-07-26
Rev Recd Date: 2021-07-23
Publish Date: 2021-12-20

Abstract

Abstract

Numerous circular RNAs (circRNAs) have been identified as vital regulators in various cancers. The newly reported circular RNA ubiquitin-associated protein 2 (circUBAP2) is a critical player in cell growth and metastasis in various types of cancers, although its role in colorectal cancer (CRC) has yet to be fully elucidated. We find that circUBAP2 is upregulated in CRC tissues and cell lines to induce autophagy both in vitro and in vivo. The effects of circUBAP2 on migration, invasion, and proliferation may be partially related to autophagy. Mechanistically, we uncover that circUBAP2 can directly interact with miR-582-5p and subsequently act as a microRNA sponge to regulate the expression of the miR-582-5p target gene forkhead box protein O1 (FOXO1) and downstream signaling molecules, which collectively advance the progression and metastasis of CRC. These results suggest that circUBAP2 acts as an oncogene via a novel circUBAP2/miR-582-5p/FOXO1 axis, providing a potential biomarker and therapeutic target for CRC management.
- CircUBAP2,
- MiR-582-5p,
- FOXO1,
- Autophagy,
- Colon cancer

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References(51)

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