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Volume 48 Issue 10
Oct.  2021
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Article Navigation >  Journal of Genetics and Genomics  > 2021  >  48(10): 872-880

Phase separation in RNA biology

doi: 10.1016/j.jgg.2021.07.012
  •  

    School of Life Sciences, Tsinghua University, Beijing 100084, China

Funds:

We apologize for being unable to cite all related publications due to space limitations. We thank Drs. Pilong Li and Yijun Qi for critical reading of the manuscript. This research was funded by TsinghuaPeking Center for Life Sciences.

  • Received Date: 2021-05-21
  • Accepted Date: 2021-07-20
  • Rev Recd Date: 2021-07-19
  • Publish Date: 2021-08-08
    Abstract
  • The formation of biomolecular condensates via liquid-liquid phase separation (LLPS) is an advantageous strategy for cells to organize subcellular compartments for diverse functions. The involvement of LLPS is more widespread and overrepresented in RNA-related biological processes. This is in part because that RNAs are intrinsically multivalent macromolecules, and the presence of RNAs affects the formation, dissolution, and biophysical properties of biomolecular condensates formed by LLPS. Emerging studies have illustrated how LLPS participates in RNA transcription, splicing, processing, quality control, translation, and function. The interconnected regulation between LLPS and RNAs ensures tight control of RNA-related cellular functions.
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