Organelle aging: Lessons from model organisms

Mark Bouska; Kerui Huang; Ping Kang; Hua Bai

doi:10.1016/j.jgg.2019.03.011

Volume 46 Issue 4

Apr. 2019

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Article Navigation > Journal of Genetics and Genomics > 2019 > 46(4): 171-185

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Organelle aging: Lessons from model organisms

doi: 10.1016/j.jgg.2019.03.011

Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, 50011, USA

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Corresponding author: E-mail address: hbai@iastate.edu (Hua Bai)
Received Date: 2018-11-20
Accepted Date: 2019-03-12
Rev Recd Date: 2019-02-22

Available Online: 2019-04-25

Publish Date: 2019-04-20

Abstract

Abstract

Most cellular processes descend into failure during aging. While a large collection of longevity pathways has been identified in the past decades, the mechanism for age-related decline of cellular homeostasis and organelle function remains largely unsolved. It is known that many organelles undergo structural and functional changes during normal aging, which significantly contributes to the decline of tissue function at old ages. Since recent studies have revealed an emerging role of organelles as regulatory hubs in maintaining cellular homeostasis, understanding of organelle aging will provide important insights into the cellular basis of organismal aging. Here we review current progress on the characterization of age-dependent structural and functional alterations in the more well-studied organelles, as well as the known mechanisms governing organelle aging in model organisms, with a special focus on the fruit fly Drosophila melanogaster.
- Longevity,
- Mitochondria,
- Nucleus,
- Autophagosome,
- Lysosome,
- Proteasome,
- Cell membrane

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References(201)

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