Fruit fly research in China

Ying Cheng; Dahua Chen

doi:10.1016/j.jgg.2018.09.003

Volume 45 Issue 11

Nov. 2018

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Fruit fly research in China

doi: 10.1016/j.jgg.2018.09.003

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

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Corresponding author: E-mail address: chendh@ioz.ac.cn (Dahua Chen)
Received Date: 2018-08-09
Accepted Date: 2018-09-29
Rev Recd Date: 2018-09-21

Available Online: 2018-11-03

Publish Date: 2018-11-20

Abstract

Abstract

Served as a model organism over a century, fruit fly has significantly pushed forward the development of global scientific research, including in China. The high similarity in genomic features between fruit fly and human enables this tiny insect to benefit the biomedical studies of human diseases. In the past decades, Chinese biologists have used fruit fly to make numerous achievements on understanding the fundamental questions in many diverse areas of biology. Here, we review some of the recent fruit fly studies in China, and mainly focus on those studies in the fields of stem cell biology, cancer therapy and regeneration medicine, neurological disorders and epigenetics.
- China,
- Development,
- Epigenetics,
- Fruit fly,
- Genetics,
- Neurology,
- Signaling pathway

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References

[1]	Adams, M.D., Celniker, S.E., Holt, R.A. et al. Science, 287 (2000),pp. 2185-2195
[2]	Bellen, H.J., Tong, C., Tsuda, H. Nat. Rev. Neurosci., 11 (2010),pp. 514-522
[3]	Bi, J., Xiang, Y., Chen, H. et al. J. Cell Sci., 125 (2012),pp. 3568-3577
[4]	Bi, J., Wang, W., Liu, Z. et al. Cell Metabol., 19 (2014),pp. 861-871
[5]	Brennecke, J., Aravin, A.A., Stark, A. et al. Cell, 128 (2007),pp. 1089-1103
[6]	Buchon, N., Silverman, N., Cherry, S. Nat. Rev. Immunol., 14 (2014),pp. 796-810
[7]	Cao, L., Wang, P., Gao, Y. et al. Ubiquitin E3 ligase dSmurf is essential for Wts protein turnover and Hippo signaling Biochem. Biophys. Res. Commun., 454 (2014),pp. 167-171
[8]	Chen, D., Wu, C., Zhao, S. et al. PLoS Genet., 10 (2014),p. e1004797
[9]	Chen, D., Wang, S., Tao, X. et al. J. Genet. Genomics, 45 (2018),pp. 219-222
[10]	Chen, D.S., Wang, Q., Huang, H.D. et al. Development, 136 (2009),pp. 4133-4142
[11]	Chen, H., Liu, Z., Huang, X. Hum. Mol. Genet., 19 (2010),pp. 494-505
[12]	Chen, J., Xu, N., Huang, H. et al. A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis eLife, 5 (2016)
[13]	Chen, J., Xu, N., Wang, C. et al. Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells Nat. Cell Biol., 20 (2018),pp. 152-161
[14]	Chen, W., Shi, W., Li, L. et al. Insect Biochem. Mol. Biol., 43 (2013),pp. 809-819
[15]	Cirelli, C. The genetic and molecular regulation of sleep: from fruit flies to humans Nat. Rev. Neurosci., 10 (2009),pp. 549-560
[16]	Dai, P., Akimaru, H., Ishii, S. Dev. Cell, 4 (2003),pp. 917-928
[17]	Dasgupta, S., Stevens, C.F., Navlakha, S. A neural algorithm for a fundamental computing problem Science, 358 (2017),pp. 793-796
[18]	Ding, L., Lei, Y., Han, Y. et al. Vimar is a novel regulator of mitochondrial fission through Miro PLoS Genet., 12 (2016)
[19]	Ding, L., Yang, X., Tian, H. et al. Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism EMBO J., 37 (2018)
[20]	Du, J., Zhang, J., He, T. et al. Stuxnet facilitates the degradation of polycomb protein during development Dev. Cell, 37 (2016),pp. 507-519
[21]	Fan, W., Lam, S.M., Xin, J. et al. PLoS Genet., 13 (2017)
[22]	Gonzalez, C. Nat. Rev. Cancer, 13 (2013),pp. 172-183
[23]	Gunawardane, L.S., Saito, K., Nishida, K.M. et al. Science, 315 (2007),pp. 1587-1590
[24]	Guo, J., Guo, A. Science, 309 (2005),pp. 307-310
[25]	Guo, T., Lu, Y., Li, P. et al. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity Cell Res., 23 (2013),pp. 1201-1214
[26]	Guo, Z., Wang, Z. Development, 136 (2009),pp. 3627-3635
[27]	Han, H., Pan, C., Liu, C. et al. Cell Discov., 1 (2015),p. 15006
[28]	Haramis, A.P., Begthel, H., van den Born, M. et al. Science, 303 (2004),pp. 1684-1686
[29]	Hateley, S., Hosamani, R., Bhardwaj, S.R. et al. Genomics, 108 (2016),pp. 158-167
[30]	Hosamani, R., Leib, R., Bhardwaj, S.R. et al. J. Proteome Res., 15 (2016),pp. 4165-4175
[31]	Hu, L., Xu, J., Yin, M.X. et al. Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded Cell Discov., 2 (2016),p. 15047
[32]	Huang, H., Li, Y., Szulwach, K.E. et al. AGO3 Slicer activity regulates mitochondria-nuage localization of Armitage and piRNA amplification J. Cell Biol., 206 (2014),pp. 217-230
[33]	Huang, H.L., Wang, S., Yin, M.X. et al. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association PLoS Biol., 11 (2013)
[34]	Huang, S., Zhang, Z., Zhang, C. et al. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover PLoS Biol., 11 (2013)
[35]	Huang, Y., Huang, S., Lam, S.M. et al. J. Cell Sci., 129 (2016),pp. 4034-4045
[36]	Ji, S.M., Li, C.Y., Hu, L. et al. Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A Proc. Natl. Acad. Sci. U. S. A., 114 (2017),pp. 6316-6321
[37]	Jiang, F., Lu, F., Li, P. et al. J. Genet. Genomics, 43 (2016),pp. 11-24
[38]	Jiang, X.Y., Xia, L.X., Chen, D.S. et al. Dev. Cell, 14 (2008),pp. 494-506
[39]	Jin, Y., Xu, J., Yin, M.X. et al. eLife, 2 (2013)
[40]	Koontz, L.M., Liu-Chittenden, Y., Yin, F. et al. The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression Dev. Cell, 25 (2013),pp. 388-401
[41]	Li, B., Wong, C., Gao, S.M. et al. The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating notch receptor trafficking eLife, 7 (2018)
[42]	Li, C.Y., Kan, L.J., Chen, Y. et al. Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation Cell Res., 25 (2015),pp. 1152-1170
[43]	Li, J.C. Genetics, 12 (1927),pp. 1-58
[44]	Li, M., Wen, S., Guo, X. et al. Nucleic Acids Res., 40 (2012),pp. 11714-11727
[45]	Li, Q., Li, Y., Wang, X. et al. Fbxl4 serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABAA receptor Curr. Biol., 27 (2017),pp. 3616-3625
[46]	Li, T., Tian, Y., Li, Q. et al. The Neurexin/N-Ethylmaleimide-sensitive factor (NSF) interaction regulates short term synaptic depression J. Biol. Chem., 290 (2015),pp. 17656-17667
[47]	Li, W., Yao, A., Zhi, H. et al. PLoS Genet., 12 (2016)
[48]	Li, W.Q., Li, W.N., Zou, L.H. et al. Membrane targeting of inhibitory Smads through palmitoylation controls TGF-beta/BMP signaling Proc. Natl. Acad. Sci. U. S. A., 114 (2017),pp. 13206-13211
[49]	Li, Y., Zhou, Z., Zhang, X. et al. J. Neurosci., 33 (2013),pp. 15545-15554
[50]	Li, Z., Liu, S., Cai, Y. J. Genet. Genomics, 41 (2014),pp. 649-652
[51]	Li, Z., Liu, S., Cai, Y. J. Genet. Genomics, 42 (2015),pp. 9-20
[52]	Li, Z., Zhang, Y., Han, L. et al. Dev. Cell, 24 (2013),pp. 133-143
[53]	Li, Z., Guo, Y., Han, L. et al. Stem Cell Rep., 2 (2014),pp. 135-144
[54]	Lin, G., Xu, N., Xi, R. Nature, 455 (2008),pp. 1119-1123
[55]	Lin, G., Xu, N., Xi, R. J. Mol. Cell Biol., 2 (2010),pp. 37-49
[56]	Liu, C., Bai, X., Sun, J. et al. J. Genet. Genomics, 42 (2015),pp. 409-412
[57]	Liu, K., Shen, D., Shen, J. et al. The super elongation complex drives neural stem cell fate commitment Dev. Cell, 40 (2017),pp. 537-551
[58]	Liu, L., Tian, Y., Zhang, X.Y. et al. Neurexin restricts axonal branching in columns by promoting ephrin clustering Dev. Cell, 41 (2017),pp. 94-106
[59]	Liu, M., Li, Y., Liu, A. et al. The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development eLife, 5 (2016)
[60]	Liu, Q., Yang, X., Tian, J. et al. eLife, 5 (2016)
[61]	Liu, S., Li, K., Gao, Y. et al. Proc. Natl. Acad. Sci. U. S. A., 115 (2018),pp. 139-144
[62]	Liu, T.Q., Wang, Q., Li, W.Q. et al. FASEB J., 31 (2017),pp. 2185-2194
[63]	Liu, W., Jiang, F., Bi, X. et al. Hum. Mol. Genet., 21 (2012),pp. 4655-4668
[64]	Liu, Y., Wang, W., Shui, G. et al. CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway PLoS Genet., 10 (2014)
[65]	Liu, Z., Huang, Y., Hu, W. et al. J. Neurosci., 34 (2014),pp. 2785-2796
[66]	Lv, X., Pan, C., Zhang, Z. et al. Development, 143 (2016),pp. 1655-1662
[67]	Ma, B., Chen, Y., Chen, L. et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase Nat. Cell Biol., 17 (2015),pp. 95-103
[68]	Ma, M., Zhao, H., Zhao, H. et al. Dev. Biol., 411 (2016),pp. 207-216
[69]	Ma, X., Huang, J., Tian, Y. et al. Myc suppresses tumor invasion and cell migration by inhibiting JNK signaling Oncogene, 36 (2017),pp. 3159-3167
[70]	Ma, X., Guo, X., Richardson, H.E. et al. POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation Proc. Natl. Acad. Sci. U. S. A., 115 (2018),pp. 2150-2155
[71]	Ma, X., Chen, Y., Xu, W. et al. Impaired Hippo signaling promotes Rho1-JNK-dependent growth Proc. Natl. Acad. Sci. U. S. A., 112 (2015),pp. 1065-1070
[72]	Ma, Z., Liu, Z., Huang, X. Development, 137 (2010),pp. 3775-3784
[73]	Park, M., Wu, X., Golden, K. et al. Dev. Biol., 177 (1996),pp. 104-116
[74]	Qian, Y., Cao, Y., Deng, B. et al. eLife, 6 (2017),p. e26519
[75]	Reiter, L.T., Potocki, L., Chien, S. et al. Genome Res., 11 (2001),pp. 1114-1125
[76]	Ren, Q., Li, H., Wu, Y. et al. J. Neurosci., 32 (2012),pp. 11524-11538
[77]	Ren, W., Zhang, Y., Li, M. et al. PLoS Genet., 11 (2015)
[78]	Rui, M., Qian, J., Liu, L. et al. The neuronal protein Neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for synaptic vesicle clustering J. Biol. Chem., 292 (2017),pp. 14334-14348
[79]	Shan, L., Wu, C., Chen, D. et al. Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis J. Genet. Genomics, 44 (2017),pp. 95-106
[80]	Shen, J., Lu, J., Sui, L. et al. Oncotarget, 5 (2014),pp. 11998-12015
[81]	Su, Y., Ospina, J.K., Zhang, J. et al. Sequential phosphorylation of smoothened transduces graded hedgehog signaling Sci. Signal., 4 (2011)
[82]	Sun, J., Liu, C., Bai, X. et al. Nat. Commun., 8 (2017),p. 14161
[83]	Sun, J., Wei, H.M., Xu, J. et al. Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation Nat. Commun., 6 (2015),p. 8856
[84]	Sun, M., Xing, G., Yuan, L. et al. J. Neurosci., 31 (2011),pp. 687-699
[85]	Sun, P., Quan, Z.H., Zhang, B.D. et al. Development, 137 (2010),pp. 2461-2469
[86]	Tan, C. Sci. Rec. (1942),pp. 178-187
[87]	Tan, C.C. Genetics, 31 (1946),pp. 195-210
[88]	Tang, M., Yuan, W., Fan, X. et al. Circ. Cardiovasc. Genet., 6 (2013),pp. 472-480
[89]	Tang, S., Guo, A. Science, 294 (2001),pp. 1543-1547
[90]	Tang, W., Wang, D., Shen, J. Sci. Rep., 6 (2016),p. 30236
[91]	Tian, Y., Bi, J., Shui, G. et al. PLoS Genet., 7 (2011)
[92]	Tian, Y., Li, T., Sun, M. et al. Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation Neuron, 77 (2013),pp. 311-322
[93]	Wang, C., Guo, X., Dou, K. et al. Development, 142 (2015),pp. 3321-3331
[94]	Wang, C., Zhao, R., Huang, P. et al. Dev. Biol., 378 (2013),pp. 122-140
[95]	Wang, C., Zhang, W., Yin, M.X. et al. Nat. Commun., 6 (2015),p. 6607
[96]	Wang, D., Li, J., Liu, S. et al. Sci. Rep., 7 (2017),p. 44393
[97]	Wen, D., Rivera-Perez, C., Abdou, M. et al. PLoS Genet., 11 (2015)
[98]	Wen, K., Yang, L., Xiong, T. et al. Genome Res., 26 (2016),pp. 1233-1244
[99]	Wion, D., Casadesus, J. N6-methyl-adenine: an epigenetic signal for DNA-protein interactions Nat. Rev. Microbiol., 4 (2006),pp. 183-192
[100]	Wu, B., Ma, L., Zhang, E. et al. PLoS Genet., 14 (2018)
[101]	Wu, C., Chen, Y., Wang, F. et al. PLoS Genet., 11 (2015)
[102]	Wu, H., Sun, L., Wen, Y. et al. Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans Proc. Natl. Acad. Sci. U. S. A., 113 (2016),pp. 4134-4139
[103]	Wu, X. J. Genet. Genomics, 37 (2010),pp. 593-603
[104]	Wu, X., Golden, K., Bodmer, R. Dev. Biol., 169 (1995),pp. 619-628
[105]	Wu, Y., Ren, Q., Li, H. et al. Learn. MEM, 19 (2012),pp. 478-486
[106]	Xia, L., Zheng, X., Zheng, W. et al. The niche-dependent feedback loop generates a BMP activity gradient to determine the germline stem cell fate Curr. Biol., 22 (2012),pp. 515-521
[107]	Xia, L., Jia, S., Huang, S. et al. Cell, 143 (2010),pp. 978-990
[108]	Xiao, G., Wan, Z., Fan, Q. et al. eLife, 3 (2014)
[109]	Xiong, Y., Liu, C., Zhao, Y. Decoding Ci: from partial degradation to inhibition Dev. Growth Differ., 57 (2015),pp. 98-108
[110]	Xu, K., Liu, X., Wang, Y. et al. Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming eLife, 7 (2018)
[111]	Xu, N., Wang, S.Q., Tan, D. et al. Dev. Biol., 354 (2011),pp. 31-43
[112]	Yan, Y., Wang, H., Hu, M. et al. Dev. Cell, 43 (2017),pp. 99-111
[113]	Yang, F., Zhao, R., Fang, X. et al. EMBO Rep., 16 (2015),pp. 965-974
[114]	Yang, L.L., Chen, D.S., Duan, R.H. et al. Development, 134 (2007),pp. 4265-4272
[115]	Yang, Y.Y., Xu, S.L., Xia, L.X. et al. PLoS Genet., 5 (2009)
[116]	Yao, A., Jin, S., Li, X. et al. Hum. Mol. Genet., 20 (2011),pp. 51-63
[117]	Yi, W., Zhang, Y., Tian, Y. et al. Sleep, 36 (2013),pp. 1809-1821
[118]	Yu, J., Lan, X., Chen, X. et al. Development, 143 (2016),pp. 2930-2945
[119]	Zeng, X., Sun, M., Liu, L. et al. FEBS Lett., 581 (2007),pp. 2509-2516
[120]	Zhang, G., Huang, H., Liu, D. et al. Cell, 161 (2015),pp. 893-906
[121]	Zhang, J., Du, J., Lei, C. et al. Ubpy controls the stability of the ESCRT-0 subunit Hrs in development Development, 141 (2014),pp. 1473-1479
[122]	Zhang, K., Guo, J.Z., Peng, Y. et al. Science, 316 (2007),pp. 1901-1904
[123]	Zhang, X., Ren, Q., Guo, A. J. Neurosci., 33 (2013),pp. 8784-8793
[124]	Zhang, X., Luo, D., Pflugfelder, G.O. et al. Development, 140 (2013),pp. 2917-2922
[125]	Zhang, Y., Chen, D., Wang, Z. Hum. Mol. Genet., 18 (2009),pp. 3894-3905
[126]	Zhang, Y., Guo, J., Guo, A. et al. Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner Neuroscience, 332 (2016),pp. 149-159
[127]	Zhang, Z., Li, X., Guo, J. et al. J. Neurosci., 33 (2013),pp. 5175-5181
[128]	Zhang, Z., Feng, J., Pan, C. et al. Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR J. Cell Biol., 203 (2013),pp. 575-583
[129]	Zhang, Z., Lv, X., Yin, W.C. et al. Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation Dev. Cell, 25 (2013),pp. 636-644
[130]	Zhao, R., Xuan, Y., Li, X.H. et al. Aging Cell, 7 (2008),pp. 344-354
[131]	Zhao, S., Chen, D., Geng, Q. et al. Dev. Biol., 376 (2013),pp. 163-170
[132]	Zheng, Z., Lauritzen, J.S., Perlman, E. et al. Cell, 174 (2018),pp. 730-743
[133]	Zhou, C., Rao, Y., Rao, Y. Nat. Neurosci., 11 (2008),pp. 1059-1067
[134]	Zhou, C., Huang, H., Kim, S.M. et al. J. Neurosci., 32 (2012),pp. 14281-14287
[135]	Zhou, Z., Yao, X., Li, S. et al. Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog signaling Dev. Cell, 34 (2015),pp. 58-72