WDR74 functions as a novel coactivator in TGF-β signaling

Jinquan Liu; Meiling Zhao; Bo Yuan; Shuchen Gu; Mingjie Zheng; Jian Zou; Jianping Jin; Ting Liu; Xin-Hua Feng

doi:10.1016/j.jgg.2018.08.005

Volume 45 Issue 12

Dec. 2018

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Article Navigation > Journal of Genetics and Genomics > 2018 > 45(12): 639-650

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WDR74 functions as a novel coactivator in TGF-β signaling

doi: 10.1016/j.jgg.2018.08.005

Jinquan Liu^{a, b},
Meiling Zhao^a,
Bo Yuan^a,
Shuchen Gu^a,
Mingjie Zheng^{a, c},
Jian Zou^c,
Jianping Jin^b,
Ting Liu^{a, d},
Xin-Hua Feng^{a, e}

a
MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China
b
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
c
Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310058, China
d
Department of Cell Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China
e
Department of Molecular & Cellular Biology and Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA

More Information

Corresponding author: E-mail address: liuting518@zju.edu.cn (Ting Liu); E-mail address: fenglab@zju.edu.cn (Xin-Hua Feng)
Received Date: 2018-06-11
Accepted Date: 2018-08-27
Rev Recd Date: 2018-08-09

Available Online: 2018-11-27

Publish Date: 2018-12-20

Abstract

Abstract

Smads are critical intracellular signal transducers for transforming growth factor-β (TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74 (WDR74) as a novel transcriptional coactivator for Smads in the canonical TGF-β signaling pathway. Through direct interactions with Smad proteins, WDR74 enhances TGF-β-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. Consequently, WDR74 enables stronger transcriptional responses and more robust TGF-β-induced physiological responses. Our findings have elucidated a critical role of WDR74 in regulating TGF-β signaling.
- WDR74,
- TGF-β signaling,
- Transcription,
- Growth inhibition,
- EMT

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References(46)

References

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