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Volume 45 Issue 6
Jun.  2018
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Article Navigation >  Journal of Genetics and Genomics  > 2018  >  45(6): 281-297

Advances in the development of molecular genetic tools for Mycobacterium tuberculosis

doi: 10.1016/j.jgg.2018.06.003
  • a 

    State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

  • b 

    University of Chinese Academy of Sciences, Beijing 100049, China

  • c 

    State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest Hospital, Guangzhou 510095, China

  • d 

    Department of Biological Sciences, University of Embu, P.O Box 6 -60100, Embu, Kenya

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    Abstract
  • Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. Here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference (CRISPRi), a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed.
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