Multiple analyses indicate the specific association of NR1I3, C6 and TNN with low hip BMD risk

Ying-Ying Han; Lan-Juan Zhao; Yong Lin; Hao He; Qing Tian; Wei Zhu; Hui Shen; Xiang-Ding Chen; Hong-Wen Deng

doi:10.1016/j.jgg.2017.05.004

Volume 44 Issue 6

Jun. 2017

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Article Navigation > Journal of Genetics and Genomics > 2017 > 44(6): 327-330

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Multiple analyses indicate the specific association of NR1I3, C6 and TNN with low hip BMD risk

doi: 10.1016/j.jgg.2017.05.004

1
Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China
2
Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
3
Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China
4
Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
5
Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, 410081, China
6
Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
7
Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
8
Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China
9
Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA

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Corresponding author: E-mail address: hdeng2@tulane.edu (Hong-Wen Deng)
Received Date: 2016-08-18
Accepted Date: 2017-05-04
Rev Recd Date: 2017-04-17

Available Online: 2017-05-08

Publish Date: 2017-06-20

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References(18)

References

[1]	Arden, N.K., Baker, J., Hogg, C. et al. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins J. Bone Miner. Res., 11 (1996),pp. 530-534
[2]	Do, R., Kathiresan, S., Abecasis, G.R. Exome sequencing and complex disease: practical aspects of rare variant association studies Hum. Mol. Genet., 21 (2012),pp. R1-R9
[3]	Hammer, M.B., Eleuch-Fayache, G., Gibbs, J.R. et al. Exome sequencing: an efficient diagnostic tool for complex neurodegenerative disorders Eur. J. Neurol., 20 (2012),pp. 486-492
[4]	Hendrickx, G., Boudin, E., Fijalkowski, I. et al. Variation in the Kozak sequence of WNT16 results in an increased translation and is associated with osteoporosis related parameters Bone, 59 (2014),pp. 57-65
[5]	Kanis, J.A., Oden, A., Johnell, O. et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women Osteoporos. Int., 18 (2007),pp. 1033-1046
[6]	Karasik, D., Dupuis, J., Cho, K. et al. Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHARe Bone, 46 (2010),pp. 1114-1121
[7]	Lei, S.F., Papasian, C.J., Deng, H.W. Polymorphisms in predicted miRNA binding sites and osteoporosis J. Bone Miner. Res., 26 (2011),pp. 72-78
[8]	Lu, X., Wang, Q., Hu, G. et al. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis Genes Dev., 23 (2009),pp. 1882-1894
[9]	Osabe, M., Negishi, M. Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm J. Biol. Chem., 286 (2011),pp. 35763-35769
[10]	Smith, E.N., Bloss, C.S., Badner, J.A. et al. Genome-wide association study of bipolar disorder in European American and African American individuals Mol. Psychiatry, 14 (2009),pp. 755-763
[11]	Styrkarsdottir, U., Thorleifsson, G., Eiriksdottir, B. et al. J. Bone Miner. Res., 31 (2015),pp. 173-179
[12]	Styrkarsdottir, U., Thorleifsson, G., Sulem, P. et al. Nature, 497 (2013),pp. 517-520
[13]	Swindle, C.S., Tran, K.T., Johnson, T.D. et al. Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor J. Cell Biol., 154 (2001),pp. 459-468
[14]	Takai, T. Fc receptors and their role in immune regulation and autoimmunity J. Clin. Immunol., 25 (2005),pp. 1-18
[15]	Wang, X., Chua, H.-X., Chen, P. et al. Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies Hum. Mol. Genet., 22 (2013),pp. 2303-2311
[16]	Xiong, D.H., Liu, X.G., Guo, Y.F. et al. Am. J. Hum. Genet., 84 (2009),pp. 388-398
[17]	Zhang, L., Choi, H.J., Estrada, K. et al. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density Hum. Mol. Genet., 23 (2013),pp. 1923-1933
[18]	Zheng, H.F., Forgetta, V., Hsu, Y.H. et al. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture Nature, 526 (2015),pp. 112-117