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Volume 43 Issue 8
Aug.  2016
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Article Navigation >  Journal of Genetics and Genomics  > 2016  >  43(8): 481-494

Argonaute: The executor of small RNA function

doi: 10.1016/j.jgg.2016.06.002
  • a 

    School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia

  • b 

    Advance Medical and Dental Institute, Universiti Sains Malaysia, Penang 11800, Malaysia

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  • Corresponding author: E-mail address: ghows@usm.my (Ghows Azzam)
  • Received Date: 2016-01-19
  • Accepted Date: 2016-06-17
  • Rev Recd Date: 2016-05-08
    • Available Online: 2016-06-30
  • Publish Date: 2016-08-20
    Abstract
  • The discovery of small non-coding RNAs – microRNA (miRNA), short interfering RNA (siRNA) and PIWI-interacting RNA (piRNA) – represents one of the most exciting frontiers in biology specifically on the mechanism of gene regulation. In order to execute their functions, these small RNAs require physical interactions with their protein partners, the Argonaute (AGO) family proteins. Over the years, numerous studies have made tremendous progress on understanding the roles of AGO in gene silencing in various organisms. In this review, we summarize recent progress of AGO-mediated gene silencing and other cellular processes in which AGO proteins have been implicated with a particular focus on progress made in flies, humans and other model organisms as compliment.
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