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Volume 43 Issue 4
Apr.  2016
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Article Navigation >  Journal of Genetics and Genomics  > 2016  >  43(4): 187-197

The Protein Arginine Methylase 5 (PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage

doi: 10.1016/j.jgg.2016.02.007
  • a 

    State Key Laboratory of Molecular and Developmental Biology, Center for Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

  • b 

    Graduate University of the Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100039, China

  • c 

    The State Key Laboratory of Plant Genomics, Center for Genome Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

More Information
  • Corresponding author: E-mail address: slbao@genetics.ac.cn (Shilai Bao)
  • Received Date: 2016-01-08
  • Accepted Date: 2016-02-15
  • Rev Recd Date: 2016-02-06
    • Available Online: 2016-03-14
  • Publish Date: 2016-04-20
    Abstract
  • Plant root stem cells and their surrounding microenvironment, namely the stem cell niche, are hypersensitive to DNA damage. However, the molecular mechanisms that help maintain the genome stability of root stem cells remain elusive. Here we show that the root stem cells in the skb1 (Shk1 kinase binding protein 1) mutant undergoes DNA damage-induced cell death, which is enhanced when combined with a lesion of the Ataxia-telangiectasia mutated (ATM) or the ATM/RAD3-related (ATR) genes, suggesting that the SKB1 plays a synergistically effect with ATM and ATR in DNA damage pathway. We also provide evidence that SKB1 is required for the maintenance of quiescent center (QC), a root stem cell niche, under DNA damage treatments. Furthermore, we report decreased and ectopic expression of SHORTROOT (SHR) in response to DNA damage in the skb1 root tips, while the expression of SCARECROW (SCR) remains unaffected. Our results uncover a new mechanism of plant root stem cell maintenance under DNA damage conditions that requires SKB1.
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    • References(42)
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    1. Qiu, C., Wang, T., Wang, H. et al. SISTER OF FCA physically associates with SKB1 to regulate flowering time in Arabidopsis thaliana. BMC Plant Biology, 2024, 24(1): 188. doi:10.1186/s12870-024-04887-y
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    3. Yin, C., Sun, A., Guo, T. et al. Arabidopsis lamin-like proteins CRWN1 and CRWN2 interact with SUPPRESSOR of NPR1-1 INDUCIBLE 1 and RAD51D to prevent DNA damage. Plant Cell, 2023, 35(9): 3345-3362. doi:10.1093/plcell/koad169
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    5. Cao, H., Liang, Y., Zhang, L. et al. AtPRMT5-mediated AtLCD methylation improves Cd2 + tolerance via increased H2S production in Arabidopsis. Plant Physiology, 2022, 190(4): 2637-2650. doi:10.1093/plphys/kiac376
    6. Drozda, A., Kurpisz, B., Arasimowicz-Jelonek, M. et al. Nitric Oxide Implication in Potato Immunity to Phytophthora infestans via Modifications of Histone H3/H4 Methylation Patterns on Defense Genes. International Journal of Molecular Sciences, 2022, 23(7): 4051. doi:10.3390/ijms23074051
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