Circulating miRNAs in Ageing and Ageing-Related Diseases

Hwa Jin Jung; Yousin Suh

doi:10.1016/j.jgg.2014.07.003

Volume 41 Issue 9

Sep. 2014

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Article Navigation > Journal of Genetics and Genomics > 2014 > 41(9): 465-472

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Circulating miRNAs in Ageing and Ageing-Related Diseases

doi: 10.1016/j.jgg.2014.07.003

Hwa Jin Jung^a,
Yousin Suh^{a, b}

a
Department of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY 11363, USA
b
Ageing Research Institute, Guangdong Medical College, Dongguan 523808, China

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Corresponding author: E-mail address: yousin.suh@einstein.yu.edu (Yousin Suh)
Received Date: 2014-02-21
Accepted Date: 2014-07-24
Rev Recd Date: 2014-06-25

Available Online: 2014-08-06

Publish Date: 2014-09-20

Abstract

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They are involved in important biological processes including development, homeostasis, and ageing. Recently, extracellular miRNAs have been discovered in the bloodstream and bodily fluids. These miRNAs are shown to be secreted and circulating in microvesicles (MVs), or in complex with other factors such as RNA-binding proteins and high-density lipoprotein (HDL) particles. These cell-free, circulating miRNAs can be taken into and function as negative regulators of target genes in recipient cells. Here we review the biogenesis and uptake of circulating miRNAs as well as their profiles in ageing and ageing-related diseases. We discuss the emerging role of circulating miRNAs as biomarkers and therapeutic targets.
- Circulating miRNAs,
- Ageing,
- Ageing-related disease,
- Biomarkers

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References

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