The Epigenetic Switches for Neural Development and Psychiatric Disorders

Jingwen Lv; Yongjuan Xin; Wenhao Zhou; Zilong Qiu

doi:10.1016/j.jgg.2013.04.007

Volume 40 Issue 7

Jul. 2013

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Article Navigation > Journal of Genetics and Genomics > 2013 > 40(7): 339-346

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The Epigenetic Switches for Neural Development and Psychiatric Disorders

doi: 10.1016/j.jgg.2013.04.007

a
Institute of Neuroscience, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
b
Department of Neonatology, Children's Hospital of Fudan University, Shanghai 201102, China

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Corresponding author: E-mail address: zhou_wenhao@yahoo.com.cn (Wenhao Zhou); E-mail address: zqiu@ion.ac.cn (Zilong Qiu)
Received Date: 2013-01-26
Accepted Date: 2013-04-30
Rev Recd Date: 2013-04-19

Available Online: 2013-05-09

Publish Date: 2013-07-20

Abstract

Abstract

The most remarkable feature of the nervous system is that the development and functions of the brain are largely reshaped by postnatal experiences, in joint with genetic landscapes. The nature vs. nurture argument reminds us that both genetic and epigenetic information is indispensable for the normal function of the brain. The epigenetic regulatory mechanisms in the central nervous system have been revealed over last a decade. Moreover, the mutations of epigenetic modulator genes have been shown to be implicated in neuropsychiatric disorders, such as autism spectrum disorders. The epigenetic study has initiated in the neuroscience field for a relative short period of time. In this review, we will summarize recent discoveries about epigenetic regulation on neural development, synaptic plasticity, learning and memory, as well as neuropsychiatric disorders. Although the comprehensive view of how epigenetic regulation contributes to the function of the brain is still not completed, the notion that brain, the most complicated organ of organisms, is profoundly shaped by epigenetic switches is widely accepted.
- DNA methylation,
- Adult neurogenesis,
- Neural plasticity,
- Learning and memory,
- Autism,
- Depression

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