Overlapping Cardiac Programs in Heart Development and Regeneration

Yi-Song Zhen; Qing Wu; Cheng-Lu Xiao; Nan-Nan Chang; Xu Wang; Lei Lei; Xiaojun Zhu; Jing-Wei Xiong

doi:10.1016/j.jgg.2012.07.005

Volume 39 Issue 9

Sep. 2012

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Article Navigation > Journal of Genetics and Genomics > 2012 > 39(9): 443-449

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Overlapping Cardiac Programs in Heart Development and Regeneration

doi: 10.1016/j.jgg.2012.07.005

a
Institute of Molecular Medicine, Peking University, Beijing 100871, China
b
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China

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Corresponding author: E-mail address: jingwei_xiong@pku.edu.cn (Jing-Wei Xiong)
Received Date: 2012-05-06
Accepted Date: 2012-07-07
Rev Recd Date: 2012-07-02

Available Online: 2012-08-11

Publish Date: 2012-09-20

Abstract

Abstract

Gaining cellular and molecular insights into heart development and regeneration will likely provide new therapeutic targets and opportunities for cardiac regenerative medicine, one of the most urgent clinical needs for heart failure. Here we present a review on zebrafish heart development and regeneration, with a particular focus on early cardiac progenitor development and their contribution to building embryonic heart, as well as cellular and molecular programs in adult zebrafish heart regeneration. We attempt to emphasize that the signaling pathways shaping cardiac progenitors in heart development may also be redeployed during the progress of adult heart regeneration. A brief perspective highlights several important and promising research areas in this exciting field.
- Cardiac progenitors,
- Heart development,
- Heart regeneration,
- Zebrafish

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References(57)

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