New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout

Meng-Wen Hu; Zhen-Bo Wang; Heide Schatten; Qing-Yuan Sun

doi:10.1016/j.jgg.2012.01.004

Volume 39 Issue 2

Feb. 2012

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New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout

doi: 10.1016/j.jgg.2012.01.004

a
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
b
Graduate School of Chinese Academy of Sciences, Beijing 100101, China
c
Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA

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Corresponding author: E-mail address: sunqy1@yahoo.com (Qing-Yuan Sun)
Received Date: 2011-11-26
Accepted Date: 2012-01-05
Rev Recd Date: 2011-12-28

Available Online: 2012-01-24

Publish Date: 2012-02-20

Abstract

Abstract

In comparison to conventional knockout technology and in vitro research methods, conditional gene knockout has remarkable advantages. In the past decade, especially during the past five years, conditional knockout approaches have been used to study the regulation of folliculogenesis, follicle growth, oocyte maturation and other major reproductive events. In this review, we summarize the recent findings about folliculogenesis/oogenesis regulation, including the functions of four signaling cascades or glycoprotein domains that have been extensively studied by conditional gene deletion. Several other still fragmented areas of related work are introduced which are awaiting clarification. We have also discussed the future potential of this technology in clarifying gene functions in reproductive biology.
- Conditional knockout,
- Folliculogenesis,
- Oogenesis,
- Mouse

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References(52)

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