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Volume 38 Issue 3
Mar.  2011
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Article Navigation >  Journal of Genetics and Genomics  > 2011  >  38(3): 95-109

The impact of next-generation sequencing on genomics

doi: 10.1016/j.jgg.2011.02.003
  • a 

    COE for Neurosciences, Department of Anesthesiology, Texas Tech University Health Sciences Center El Paso, TX 79905, USA

  • b 

    Department of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, TX 79905, USA

  • c 

    Internal Medicine, Texas Tech University Health Sciences Center El Paso, TX 79905, USA

  • d 

    College of Life Sciences, Beijing Normal University, Beijing 100875, China

More Information
  • Corresponding author: E-mail address: jun.zhang2000@gmail.com (Jun Zhang)
  • Received Date: 2010-11-02
  • Accepted Date: 2011-01-18
  • Rev Recd Date: 2011-01-18
    • Available Online: 2011-03-15
  • Publish Date: 2011-03-20
    Abstract
  • This article reviews basic concepts, general applications, and the potential impact of next-generation sequencing (NGS) technologies on genomics, with particular reference to currently available and possible future platforms and bioinformatics. NGS technologies have demonstrated the capacity to sequence DNA at unprecedented speed, thereby enabling previously unimaginable scientific achievements and novel biological applications. But, the massive data produced by NGS also presents a significant challenge for data storage, analyses, and management solutions. Advanced bioinformatic tools are essential for the successful application of NGS technology. As evidenced throughout this review, NGS technologies will have a striking impact on genomic research and the entire biological field. With its ability to tackle the unsolved challenges unconquered by previous genomic technologies, NGS is likely to unravel the complexity of the human genome in terms of genetic variations, some of which may be confined to susceptible loci for some common human conditions. The impact of NGS technologies on genomics will be far reaching and likely change the field for years to come.
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