Patterning mechanisms controlling digit development

Jianxin Hu; Lin He

doi:10.1016/S1673-8527(08)60071-5

Volume 35 Issue 9

Sep. 2008

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Article Navigation > Journal of Genetics and Genomics > 2008 > 35(9): 517-524

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Patterning mechanisms controlling digit development

doi: 10.1016/S1673-8527(08)60071-5

Jianxin Hu^a,
Lin He^{a, b, c}

a
Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
b
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
c
Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China

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Corresponding author: E-mail address: helin@bio-x.cn (Lin He)
Received Date: 2008-05-21
Accepted Date: 2008-06-15
Rev Recd Date: 2008-06-14

Available Online: 2008-09-17

Publish Date: 2008-09-20

Abstract

Abstract

Vertebrate digits are essential structures for movement, feeding and communication. Specialized regions of the developing limb bud including the zone of polarizing activity (ZPA), the apical ectodermal ridge (AER), and the non-ridge ectoderm regulate the patterning of digits. Although a series of signaling molecules have been characterized as patterning signals from the organizing centers, the delicate cellular and molecular mechanisms that interpret how these patterning signals control the detailed digit anatomy remain unclear. Recent studies from model organisms and human hand malformations provide new insights into the mechanisms regulating this process. Here, we review the current understanding of the genetic networks governing digit morphogenesis.
- digit formation,
- AER,
- ZPA,
- Shh gradient,
- patterning mechanism,
- specification,
- elongation,
- segmentation

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References(65)

References

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