Genetic polymorphism of mitochondrial DNA HVS-I and HVS-II of Chinese Tu ethnic minority group

Feng Chen; Yajun Deng; Yonghui Dang; Bo Zhang; Haofang Mu; Xiaoguang Yu; Lin Li; Chunxia Yan; Teng Chen

doi:10.1016/S1673-8527(08)60031-4

Volume 35 Issue 4

Apr. 2008

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Article Navigation > Journal of Genetics and Genomics > 2008 > 35(4): 225-232

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Genetic polymorphism of mitochondrial DNA HVS-I and HVS-II of Chinese Tu ethnic minority group

doi: 10.1016/S1673-8527(08)60031-4

Feng Chen^{a, b, c, d, #},
Yajun Deng^{a, b, c, d, #},
Yonghui Dang^{a, b},
Bo Zhang^d,
Haofang Mu^d,
Xiaoguang Yu^d,
Lin Li^a,
Chunxia Yan^{a, b, c, d},
Teng Chen^{a, b}

a
Department of Forensic Science, Xi'an Jiaotong University School of Medicine, Shaanxi 710061, China
b
Key Laboratory of Forensic Medicine, Ministry of Health, Xi'an Jiaotong University, Shaanxi 710061, China
c
Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 100029, China
d
Center of Forensic Sciences, Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China

More Information

Corresponding author: E-mail address: chenteng@mail.xjtu.edu.cn (Teng Chen)
Received Date: 2007-12-11
Accepted Date: 2008-01-09
Rev Recd Date: 2008-01-09

Available Online: 2008-04-24

Publish Date: 2008-04-20

Abstract

Abstract

We analyzed the two hypervariable segments HVS-I and HVS-II of 108 Chinese Tu ethnic minority group samples for forensic and population genetics purposes. Comparing with Anderson sequence, 79 polymorphic loci in HVS-I and 40 in HVS-II were found in Chinese Tu ethnic minority group mtDNA sequences, and 90 and 64 haplotypes were then defined. Haplotype diversity and the mean pairwise differences were 0.9903±0.0013 and 5.7785 in HVS-I, and 0.9777±0.0013 and 3.5819 in HVS-II, respectively. By analyzing the hypervariable domain from nucleotide 1,6180 to 1,6193 in HVS-I, we defined some new types of sequence variations. We also compared the relationship between Tu population and other populations using mtDNA HVS-I sequences. According to Rst genetic distances, the phylogenetic tree showed that the Tu population, the Xi'an Han population, the Chinese Korean, and the Mongol ethnic group were in a clade. This indicated a close genetic relationship between them. There were far relations between the Tu population and other Chinese southern Han populations, Siberian, European, African, and other foreign populations. The results suggest that Tu population has a multi-origin and has also merged with other local populations.
- mtDNA,
- HVS-I,
- HVS-II,
- Chinese Tu ethnic minority group,
- population genetics

They contributed equally to this work.

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References(26)

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