Identification of Differentially Expressed MicroRNAs During the Development of Chinese Murine Mammary Gland

Chunmei Wang; Qingzhang Li

doi:10.1016/S1673-8527(07)60109-X

Volume 34 Issue 11

Nov. 2007

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Article Navigation > Journal of Genetics and Genomics > 2007 > 34(11): 966-973

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Identification of Differentially Expressed MicroRNAs During the Development of Chinese Murine Mammary Gland

doi: 10.1016/S1673-8527(07)60109-X

Key laboratory Dairy Science of Education Ministry Northeast Agricultural University, Harbin 15000, China

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Corresponding author: E-mail address: qingzhangli2004@163.com (Qingzhang Li)
Received Date: 2007-02-26
Accepted Date: 2007-04-09

Available Online: 2007-11-22

Publish Date: 2007-11-20

Abstract

Abstract

MicroRNAs (miRNAs) are endogenous ∼22 nucleotide-long noncoding RNAs. In this study, to investigate miRNA expression profiles and their functions in mammary gland development, we have used microarray as well as qRT-PCR, to analyze the miRNA expression changes along the murine mammary cycle during pregnancy, particularly on transition from pregnancy to lactation. It shows that every developmental stage of the mammary gland has its own miRNA expression pattern. Compared with virgin and involution, some miRNAs such as miR-138 and miR-431 are downregulated, whereas, some miRNAs such as miR-133 and miR-133a-133b are upregulated during pregnancy and lactation. These results indicate that miRNAs are functionally involved in mammary gland development.
- microRNA (miRNA),
- microarray,
- mammary pregnancy cycle,
- gene expression regulation

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References(20)

References

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