IGF-1-mediated upregulation of gut <i>Blautia</i> correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

Zekun Deng; Siyu Chen; Yong She; Yunzhi Zou; Zeming Yan; Jintong Cheng; Guanghao Yue; Depei Li; Qi Zhao; Xia Zhao; Xiaobing Jiang

doi:10.1016/j.jgg.2025.04.015

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IGF-1-mediated upregulation of gut Blautia correlates with inflammatory markers in growth hormone-secreting pituitary adenomas

doi: 10.1016/j.jgg.2025.04.015

1. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
2. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China;
3. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
4. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China;
5. Department of Neurosurgery/Neuro-Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China;
6. Department of Microbiology, Army Medical University, Chongqing 400038, China;
7. Cancer Microbiome Platform, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China

Funds:

This study was supported by the National Natural Science Foundation of China (82372624 to X.J.), and Guangdong Basic and Applied Basic Research Foundation (2024A1515013102 and 2022A1515012430 to X.J.). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.