The phospholipid scramblase PLSCR5 is regulated by POU4F3 and required for hair cell stereocilia homeostasis and auditory functions

doi: 10.1016/j.jgg.2025.03.003

• Sihao Gong ^a,b , 
• Qing Liu ^a,b,c , 
• Haibo Du ^d , 
• Linqing Zhang ^a,b , 
• Chengwen Zhu ^a,c , 
• Zhigang Xu ^d , 
• Xia Gao ^a,c     , 
• Guang-Jie Zhu ^a,c     , 
• Guoqiang Wan ^a,b,c    

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  a. MOE Key Laboratory of Model Animal for Disease Study, Department of Otolaryngology Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), The Affiliated Drum Tower Hospital of Medical School and the Model Animal Research Center of Medical School, Nanjing University, Nanjing, Jiangsu 210008, China;

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  b. State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine, National Resource Center for Mutant Mice of China, Nanjing University, Nanjing, Jiangsu 210008, China;

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  c. Research Institute of Otolaryngology, No. 321 Zhongshan Road, Nanjing, Jiangsu 210008, China;

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  d. Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology and Key Laboratory for Experimental Teratology of the Ministry of Education, School of Life Sciences, Shandong University, Qingdao, Shandong 266237, China