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Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

doi: 10.1016/j.jgg.2025.01.015
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it was their contributions that made this study possible. C.L., Q.L., and Q.X. contributed equally to this work. This work was supported by grants from the National Key Research and Development Program of China (2022YFA1303900, 2021YFC2700705), and the National Natural Science Foundation of China (82103919). The funding sources had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

We would like to thank the well-dedicated women and staff who participated in this cohort study

  • Received Date: 2025-01-16
  • Accepted Date: 2025-01-19
  • Available Online: 2025-07-11
  • The impact of mother-infant microbiota on neurodevelopment is an area of interest, but longitudinal studies are scarce. Using a cohort of 520 families from the Jiangsu birth cohort in China, we reveal that the maternal gut microbiota during early pregnancy play a substantial role, accounting for 3.34% of the variance in offspring neurodevelopmental scores. This contribution is notably higher than the 1.24% attributed to the infants’ own microbiota at 1 year of age, underscoring the significant influence of maternal gut health on early child development. Remarkably, an elevation in maternal Bifidobacterium pseudocatenulatum is linked to decreased cognitive scores, whereas an enrichment of Bifidobacterium longum at 1 year of age is associated with higher cognitive scores. Furthermore, we find that maternal B. pseudocatenulatum is linked to the heterolactic fermentation metabolic pathway, while infant B. longum is associated with the Bifidobacterium shunt pathway. In summary, our analysis implies that maternal and infant gut microbiota play a distinct role in neurodevelopment, suggesting potential strategies for improving neurodevelopmental outcomes during early pregnancy or infant development by targeting gut microbiota composition.

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      沈阳化工大学材料科学与工程学院 沈阳 110142

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