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Volume 52 Issue 5
May  2025
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Article Navigation >  Journal of Genetics and Genomics  > 2025  >  52(5): 601-614

Deciphering the influence of gut and oral microbiomes on menopause for healthy aging

doi: 10.1016/j.jgg.2024.11.010
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    a. Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China;

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    b. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing 100730, China;

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    c. Beijing ClouDNA Technology Co., Ltd., Beijing 101407, China;

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    d. Hunan Agriculture University, Changsha, Hunan 410128, China;

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    e. Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;

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    f. Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Rare Disease Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China

Funds:

This work was supported by Science & Technology Fundamental Resources Investigation Program (2022FY100800), the CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-1-023/2023-I2M-C&T-B-005), Funding for Reform and Development of Beijing Municipal Health Commission, and the National High Level Hospital Clinical Research Funding (2022-PUMCH-B-094).

  • Received Date: 2024-09-27
  • Accepted Date: 2024-11-14
  • Rev Recd Date: 2024-11-08
    • Available Online: 2025-07-11
  • Publish Date: 2024-11-21
    Abstract
  • Menopause is characterized by the cessation of menstruation and a decline in reproductive function, which is an intrinsic component of the aging process. However, it has been a frequently overlooked field of women's health. The oral and gut microbiota, constituting the largest ecosystem within the human body, are important for maintaining human health and notably contribute to the healthy aging of menopausal women. Therefore, a comprehensive review elucidating the impact of the gut and oral microbiota on menopause for healthy aging is of paramount importance. This paper presents the current understanding of the microbiome during menopause, with a particular focus on alterations in the oral and gut microbiota. Our study elucidates the complex interplay between the microbiome and sex hormone levels, explores microbial crosstalk dynamics, and investigates the associations between the microbiome and diseases linked to menopause. Additionally, this review explores the potential of microbiome-targeting therapies for managing menopause-related diseases. Given that menopause can last for approximately 30 years, gaining insights into how the microbiome and menopause interact could pave the way for innovative interventions, which may result in symptomatic relief from menopause and an increase in quality of life in women.
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