ERVcancer: a web resource designed for querying activation of human endogenous retroviruses across major cancer types

Xiaoyun Lei; Song Mao; Yinshuang Li; Shi Huang; Jinchen Li; Wei Du; Chunmei Kuang; Kai Yuan

doi:10.1016/j.jgg.2024.09.004

Volume 52 Issue 4

Apr. 2025

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ERVcancer: a web resource designed for querying activation of human endogenous retroviruses across major cancer types

doi: 10.1016/j.jgg.2024.09.004

a. Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;
b. Guangxi Health Commission Key Laboratory of Medical Genetics and Genomics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530007, China;
c. Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410000, China;
d. Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan 415000, China;
e. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;
f. Furong Laboratory, Changsha, Hunan 410000, China;
g. The Biobank of Xiangya Hospital, Central South University, Changsha, Hunan 410008, China

Funds:

We gratefully acknowledge Dr. Guihu Zhao and members of the Yuan Lab for inspiring discussions and technical assistance. This project has been supported by the National Natural Science Foundation of China (32370821, 32170821, and 92153301 to K.Y), National Key Research and Development Program of China (2021YFC2701200), Department of Science & Technology of Hunan Province (2023RC1028, and 2023SK2091 to K.Y), Middle/Young aged Teachers' Research Ability Improvement Project of Guangxi Higher Education (2024KY0111 to X.L), and Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation (2023JJB140356 to X.L).

Received Date: 2024-05-13
Accepted Date: 2024-09-05
Rev Recd Date: 2024-09-04

Available Online: 2025-07-11

Publish Date: 2024-09-10

Abstract

Abstract

Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome, integrated into the dynamic regulatory network of cellular potency during early embryonic development. In recent studies, resurgent the transcriptional activity of HERVs has been frequently observed in many types of human cancers, suggesting their potential functions in the occurrence and progression of malignancy. However, a dedicated web resource for querying the relationship between the activation of HERVs and cancer development is lacking. Here, we construct a database to explore the sequence information, expression profiles, survival prognosis, and genetic interactions of HERVs in diverse cancer types. Our database currently contains RNA sequencing data of 580 HERVs across 16,246 samples, including that of 6478 tumoral and 634 normal tissues, 932 cancer cell lines, as well as 151 early embryonic and 8051 human adult tissues. The primary goal is to provide an easily accessible and user-friendly database for professionals in the fields of bioinformatics, pathology, pharmacology, and related areas, enabling them to efficiently screen the activity of HERVs of interest in normal and cancerous tissues and evaluate the clinical relevance. The ERVcancer database is available at http://kyuanlab.com/ervcancer/.
- Human endogenous retrovirus,
- Expression profile,
- Cancer,
- Differential expression,
- Survival prognosis,
- KZFPs

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