TAZ inhibits SCLC metastasis through GALNT18-mediated <i>O</i>-glycosylation

Zhiwei Zhang; Zhijue Xu; Xinyi Qian; Yanxu Chen; Duo Li; Zhen Qin; Luonan Chen; Yan Zhang; Yujuan Jin; Hongbin Ji

doi:10.1016/j.jgg.2024.09.001

Volume 51 Issue 11

Nov. 2024

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Article Navigation > Journal of Genetics and Genomics > 2024 > 51(11): 1314-1317

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TAZ inhibits SCLC metastasis through GALNT18-mediated O-glycosylation

doi: 10.1016/j.jgg.2024.09.001

Zhiwei Zhang^1,2,
Zhijue Xu³,
Xinyi Qian^4,5,
Yanxu Chen^4,5,
Duo Li⁶,
Zhen Qin⁶,
Luonan Chen^7,8,9,
Yan Zhang¹⁰,
Yujuan Jin¹¹,
Hongbin Ji^12,13,14,15

1. State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China;
3. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China;
4. State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;
5. University of Chinese Academy of Sciences, Beijing 100049, China;
6. State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;
7. State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;
8. Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, Zhejiang 330106, China;
9. Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, China;
10. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China;
11. State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;
12. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China;
13. University of Chinese Academy of Sciences, Beijing 100049, China;
14. School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310024, China;
15. School of Life Science and Technology, Shanghai Tech University, Shanghai 200120, China

Funds:

82273400 to Y.J.

This work was supported by the National Key Research and Development Program of China (grants 2022YFA1103900, 2020YFA0803300 to H.J.

32071271 to Y.Z.

82303039 to Z.Q.

2022YFA1004800 to L.C.), the National Natural Science Foundation of China (grants 82341002, 32293192, 82030083 to H.J.

T2350003, T2341007, 12131020, 31930022 to L.C.), the Innovative Research Team of High-level Local Universities in Shanghai (SSMU-ZLCX20180500 to H.J.), Science and Technology Commission of Shanghai Municipality (23JS1401300 to L.C.), and the Japan Science and Technology Agency Moonshot R&D (JPMJMS2021 to L.C.).

Received Date: 2024-06-20
Accepted Date: 2024-09-01
Rev Recd Date: 2024-08-29

Available Online: 2025-06-06

Publish Date: 2024-09-10

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References(13)

References

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