<i>Toll-9</i> prevents the proliferation of injected oncogenic cells in adult flies

Shanming Ji; Jules A. Hoffmann

doi:10.1016/j.jgg.2024.07.002

Volume 51 Issue 11

Nov. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Genetics and Genomics > 2024 > 51(11): 1331-1333

PDF( 772 KB)

Toll-9 prevents the proliferation of injected oncogenic cells in adult flies

doi: 10.1016/j.jgg.2024.07.002

Shanming Ji¹,
Jules A. Hoffmann^1,2

1. Insect Models of Innate Immunity (M3I;
9022), Institute of Molecular and Cellular Biology, CNRS, Strasbourg 67084, France;
1a. Insect Models of Innate Immunity (M3I;
9022), Institute of Molecular and Cellular Biology, CNRS, Strasbourg 67084, France;
2. Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, Guangdong 511436, China

Funds:

Additional support has been provided by the University of Strasbourg Institute for Advanced Study (to J.A.H.) and the International Science and Technology Innovation Cooperation between Governments for National Key R&D Program Projects (2023YFE0107700).

Received Date: 2024-04-28
Accepted Date: 2024-07-01
Rev Recd Date: 2024-07-01

Available Online: 2025-06-06

Publish Date: 2024-07-06

Abstract

FullText(HTML)

References(13)

References

Akira, S., Uematsu, S., Takeuchi, O., 2006. Pathogen recognition and innate immunity. Cell 124, 783-801.

Anderson, K.V., Bokla, L., Nusslein-Volhard, C., 1985. Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 42, 791-798.

Chen, D., Lan, X., Huang, X., Huang, J., Zhou, X., Liu, J., and Hoffmann, J.A., 2023. mthl1, a potential Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies. Proc. Natl. Acad. Sci. U. S. A. 120, e2303462120.

Chen, D., Roychowdhury-Sinha, A., Prakash, P., Lan, X., Fan, W., Goto, A., Hoffmann, J.A., 2021. A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses. Proc. Natl. Acad. Sci. U. S. A. 118, e2100825118.

Hoffmann, J.A., 2003. The immune response of Drosophila. Nature 426, 33-38.

Hoffmann, J.A., Kafatos, F.C., Janeway, C.A., Ezekowitz, R.A., 1999. Phylogenetic perspectives in innate immunity. Science 284, 1313-1318.

Ji, S., Zhou, X., Hoffmann, J.A. 2024. Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells. Cell Rep. 43, 113677.

Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., Hoffmann, J.A., 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983.

Medzhitov, R., Janeway, C., Jr., 2000. The Toll receptor family and microbial recognition. Trends Microbiol. 8, 452-456.

Nusslein-Volhard, C., 2021. The Toll gene in Drosophila pattern formation. Trends Genet. 38, 231-245.

Pendse, J., Ramachandran, P.V., Na, J., Narisu, N., Fink, J.L., Cagan, R.L., Collins, F.S., Baranski, T.J., 2013. A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. BMC Genom. 14, 136.

Sakakibara, Y., Yamashiro, R., Chikamatsu, S., Hirota, Y., Tsubokawa, Y., Nishijima, R., Takei, K., Sekiya, M., Iijima, K.M., 2023. Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration. iScience 26, 105968.

Shields, A., Amcheslavsky, A., Brown, E., Lee, T.V., Nie, Y., Tanji, T., Ip, Y.T., Bergmann, A., 2022. Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila. Cell Rep. 39, 110817.

Relative Articles

Supplements(0)

Cited By

Proportional views