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Volume 52 Issue 4
Apr.  2025
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Article Navigation >  Journal of Genetics and Genomics  > 2025  >  52(4): 460-472

Forensic investigative genetic genealogy: expanding pedigree tracing and genetic inquiry in the genomic era

doi: 10.1016/j.jgg.2024.06.016
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    a. Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu, Sichuan 610041, China;

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    b. Center for Archaeological Science, Sichuan University, Chengdu, Sichuan 610041, China;

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    c. Anti-Drug Technology Center of Guangdong Province, Guangzhou, Guangdong 510000, China;

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    d. Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China

Funds:

This study was supported by the National Natural Science Foundation of China (82202078), the Major Project of the National Social Science Foundation of China (23&ZD203), the Open Project of the Key Laboratory of Forensic Genetics of the Ministry of Public Security (2022FGKFKT05), the Center for Archaeological Science of Sichuan University (23SASA01), the 1·3·5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYJC20002), and the Sichuan Science and Technology Program (2024NSFSC1518).

  • Received Date: 2024-04-25
  • Accepted Date: 2024-06-24
  • Rev Recd Date: 2024-06-23
    • Available Online: 2025-07-11
  • Publish Date: 2024-07-03
    Abstract
  • Genetic genealogy provides crucial insights into the complex biological relationships within contemporary and ancient human populations by analyzing shared alleles and chromosomal segments that are identical by descent to understand kinship, migration patterns, and population dynamics. Within forensic science, forensic investigative genetic genealogy (FIGG) has gained prominence by leveraging next-generation sequencing technologies and population-specific genomic resources, opening useful investigative avenues. In this review, we synthesize current knowledge, underscore recent advancements, and discuss the growing role of FIGG in forensic genomics. FIGG has been pivotal in revitalizing dormant inquiries and offering genetic leads in numerous cold cases. Its effectiveness relies on the extensive single-nucleotide polymorphism profiles contributed by individuals from diverse populations to specialized genomic databases. Advances in computational genomics and the growth of human genomic databases have spurred a profound shift in the application of genetic genealogy across forensics, anthropology, and ancient DNA studies. As the field progresses, FIGG is evolving from a nascent practice into a more sophisticated and specialized discipline, shaping the future of forensic investigations.
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