Another piece of puzzle for the human microbiome: the gut virome under dietary modulation

Fengxiang Zhao; Jinfeng Wang

doi:10.1016/j.jgg.2024.04.013

Volume 51 Issue 10

Oct. 2024

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Article Navigation > Journal of Genetics and Genomics > 2024 > 51(10): 983-996

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Another piece of puzzle for the human microbiome: the gut virome under dietary modulation

doi: 10.1016/j.jgg.2024.04.013

College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China

Funds:

This work was supported by the National Key Research and Development Program of China (2022YFA1304102), the National Natural Science Foundation of China (32070122, 32370053, T2341010), the Chinese Universities Scientific Fund (2023RC022), Pinduoduo-China Agricultural University Research Fund (PC2023B02015), and the 2115 Talent Development Program of China Agricultural University.

Received Date: 2024-03-02
Accepted Date: 2024-04-24
Rev Recd Date: 2024-04-24

Available Online: 2025-06-06

Publish Date: 2024-05-06

Abstract

Abstract

The virome is the most abundant and highly variable microbial consortium in the gut. Because of difficulties in isolating and culturing gut viruses and the lack of reference genomes, the virome has remained a relatively elusive aspect of the human microbiome. In recent years, studies on the virome have accumulated growing evidence showing that the virome is diet-modulated and widely involved in regulating health. Here, we review the responses of the gut virome to dietary intake and the potential health implications, presenting changes in the gut viral community and preferences of viral members to particular diets. We further discuss how viral-bacterial interactions and phage lifestyle shifts shape the gut microbiota. We also discuss the specific functions conferred by diet on the gut virome and bacterial community in the context of horizontal gene transfer, as well as the import of new viral members along with the diet. Collating these studies will expand our understanding of the dietary regulation of the gut virome and inspire dietary interventions and health maintenance strategies targeting the gut microbiota.
- Diet,
- Gut virome,
- Phage lifestyle,
- Auxiliary metabolic genes,
- Horizontal gene transfer

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References(125)

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